The Correlation between Serum Anti-β 2 Glycoprotein 1 Antibody Levels and the Stability of Carotid Atherosclerotic Plaques in Elderly Patients with H-Type Hypertension
Abstract：【Objective】To explore the correlation between serum anti-β 2 glycoprotein 1 antibody (aβ2GP1) and the stability of carotid atherosclerotic plaques in elderly patients with H-type hypertension. 【Methods】 A total of 124 elderly patients with H-type hypertension admitted to our hospital from August 2019 to October 2023 were selected. According to the results of carotid ultrasound examination, the patients were divided into the unstable plaque group (n=69) and the stable plaque group (n=55). Logistic regression analysis was used to explore the risk factors influencing the stability of carotid atherosclerotic plaques in elderly patients with H-type hypertension. The receiver operating characteristic (ROC) curve was fabricated to analyze the predictive value of serum aβ2GP1 level for unstable carotid atherosclerotic plaques in elderly patients with H-type hypertension. 【Results】 The levels of homocysteine, C-reactive protein, tumor necrosis factor-α, interleukin-1β, aβ2GP1 and IMT in the unstable plaque group were higher than those in the stable plaque group, and the difference was statistically significant (P<0.05). Logistic multifactor regression analysis showed that Hcy, aβ2GP1 all affected the elderly H-type hypertensive patients with carotid atherosclerotic plaque stability related factors (P<0.05). ROC curve analysis showed that the optimal cutoff point of serum aβ2GP1 for predicting carotid atherosclerotic unstable plaques in elderly patients with H-type hypertension was 15.24 RU/mL, with sensitivity and specificity of 72.46% and 83.64% respectively, and the area under the curve was 0.831 (95%CI: 0.753-0.892). 【Conclusion】The level of serum aβ2GP1 is related to the stability of carotid atherosclerotic plaques in elderly patients with H-type hypertension, and the level of serum aβ2GP1 can be used as an important reference indicator for predicting the stability of carotid atherosclerotic plaques in elderly patients with H-type hypertension.
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2025, Vol. 42 
