Effect of Naoxueshu Oral Liquid on Hematoma Absorption and Neuroinflammation in Patients with Residual Hematoma during Recovery after Intracerebral Hemorrhage
HAO Yingying, SONG Xiaozheng, LIU Jinhui, et al
Department of General Medicine, Zhumadian First People's Hospital, Zhumadian Henan 463000
Abstract：【Objective】 To investigate the effects of Naoxueshu Oral Liquid on hematoma absorption and neuroinflammation in patients with residual hematoma during the recovery stage of spontaneous intracerebral hemorrhage (ICH).【Methods】 A total of 78 patients with residual hematoma during ICH recovery were randomly divided into a control group and an observation group, with 39 cases in each. Both groups received standardized ICH treatment, while the observation group was additionally treated with Naoxueshu Oral Liquid. Hematoma absorption, absolute and relative perilesional edema (PHE) volume, edema resolution time, neutrophil-to-lymphocyte ratio (NLR), systemic inflammation response index (SIRI), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (GSH) levels were compared between the two groups before and after 30 days of treatment.【Results】After 30 days of treatment, hematoma volume was significantly reduced in both groups (P<0.05), with the observation group showing smaller hematoma volume, higher absorption rate, and shorter complete absorption time than the control group (all P<0.05). PHE volume decreased in both groups (P<0.05), however, the observation group had lower absolute and relative PHE volume and shorter edema resolution time than the control group (all P<0.05). After treatment, NLR, SIRI, and TNF-α levels decreased compared with pretreatment values (P<0.05), and their levels in the observation group were lower than those in the control group (P<0.05). MDA level decreased, while both SOD and GSH levels increased in both groups after treatment (all P<0.05); while the observation group exhibited lower MDA and higher levels of SOD and GSH compared to the control group (P<0.05).【Conclusion】 Naoxueshu Oral Liquid, when combined with conventional rehabilitation therapy, can significantly promote hematoma and perilesional edema absorption, alleviate neuroinflammatory responses, and improve oxidative stress status in patients during the recovery phase of ICH.
郝迎迎, 宋孝政, 刘锦辉, 田明. 脑血疏口服液对自发性脑出血恢复期血肿残留患者血肿吸收及神经炎症反应的影响[J]. 医学临床研究, 2025, 42(11): 1924-1927.
HAO Yingying, SONG Xiaozheng, LIU Jinhui, et al. Effect of Naoxueshu Oral Liquid on Hematoma Absorption and Neuroinflammation in Patients with Residual Hematoma during Recovery after Intracerebral Hemorrhage. JOURNAL OF CLINICAL RESEARCH, 2025, 42(11): 1924-1927.
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2025, Vol. 42 
