摘要【目的】探讨子宫内膜异位症患者血清中C1q/TNF相关蛋白3(C1q/TNF-related protein 3,CTRP3)、阿培林(Apelin)、抑制素B(INHB)水平与生育指数的相关性。【方法】选取2022年1月至2024年10月在本院就诊的107例子宫内膜异位症患者(观察组),另外选取同期在本院体检52例健康女性作为对照组。检测两组血清中CTRP3、Apelin、INHB水平,采用生育指数评分评估生育能力,采用Spearman相关性分析CTRP3、Apelin、INHB水平与生育指数的相关性。【结果】观察组CTRP3、INHB水平显著低于对照组,Apelin水平显著高于对照组,差异均有统计学意义(P<0.05);观察组生育指数显著低于对照组,差异有统计学意义(P<0.05)。相关性分析显示:Apelin水平与生育指数呈负相关(rs=-0.584,P<0.05),而CTRP3和INHB水平与生育指数呈正相关(rs=0.795、0.629,P<0.05)。【结论】子宫内膜异位症患者血清中CTRP3、Apelin、INHB的异常表达与其生育能力下降有关。血清中CTRP3、Apelin、INHB水平可能在子宫内膜异位症患者疾病进展和生育能力的下降中起关键作用,为未来的治疗策略提供了新的思路。
Abstract：【Objective】To investigate the correlations between the levels of C1q/TNF-related protein 3 (CTRP3), Apelin, and inhibin B (INHB) in the serum of patients with endometriosis and their reproductive indices. 【Methods】From January 2022 to October 2024, 107 patients with endometriosis who visited our hospital were selected as the observation group, and 52 healthy women who underwent physical examinations in the same period at our hospital were selected as the control group. The levels of CTRP3, Apelin, and INHB in the serum of both groups were detected. The reproductive ability was evaluated using the reproductive index score. Spearman correlation analysis was used to analyze the correlations between the levels of CTRP3, Apelin, and INHB and the reproductive index. 【Results】The levels of CTRP3 and INHB in the observation group were significantly lower than those in the control group, while the level of Apelin was significantly higher than that in the control group. The differences were statistically significant (P<0.05). The reproductive index of the observation group was significantly lower than that of the control group, and the difference was statistically significant (P<0.05). Correlation analysis showed that the level of Apelin was negatively correlated with the reproductive index score (rs=-0.584, P<0.05), while the levels of CTRP3 and INHB were positively correlated with the reproductive index (rs=0.795, 0.629, P<0.05). 【Conclusion】The abnormal expression of CTRP3, Apelin, and INHB in the serum of patients with endometriosis is related to the decline in reproductive ability. The levels of CTRP3, Apelin, and INHB in the serum may play a key role in the disease progression and the reduction of reproductive ability in patients with endometriosis, providing new ideas for future treatment strategies.
刘媛媛, 张大岭. 子宫内膜异位症患者血清中生殖相关生物标志物水平与生育指数的相关性[J]. 医学临床研究, 2025, 42(10): 1743-1745.
LIU Yuanyuan, ZHANG Daling. Analysis of the Relationship between Serum Reproductive-Related Biomarker Levels and Fertility Index in Patients with Endometriosis. JOURNAL OF CLINICAL RESEARCH, 2025, 42(10): 1743-1745.
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2025, Vol. 42 
