医学临床研究
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医学临床研究  2024, Vol. 41 Issue (5): 747-749    DOI: 10.3969/j.issn.1671-7171.2024.05.029
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丹参川芎嗪注射液联合曲美他嗪对不稳定型心绞痛患者心电图、心功能的影响
何照国, 邹洋
中国人民解放军联勤保障部队第九八九医院,河南 洛阳 471000
The Effects of Danshen Chuanxiongqin Injection Combined with Trimetazidine on Electrocardiogram and Cardiac Function Levels in Patients with Unstable Angina Pectoris
HE Zhaoguo, ZOU Yang
The 989th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China, Luoyang Henan 471000
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摘要 【目的】探讨丹参川芎嗪注射液联合曲美他嗪对不稳定型心绞痛(UAP)患者心电图、心功能的影响。【方法】回顾性分析2021年1月至2023年5月本院收治的106例UAP患者的临床资料,根据治疗方法的不同将其分为对照组和观察组,每组53例。对照组采用曲美他嗪治疗,观察组采用丹参川芎嗪注射液+曲美他嗪治疗。比较两组临床疗效、发作频率、硝酸甘油用量、持续时间、心功能指标[心排血量(CO)、左心室射血分数(LVEF)、每搏输出量(SV)]、心电图变化情况[ST段压低幅度、ST段压低次数]、血清生化指标[血管生成素样蛋白2(Angptls2)、氧化型低密度脂蛋白(ox-LDL)、C1q肿瘤坏死因子相关蛋白1(CTRP1)]及不良反应发生情况。【结果】观察组有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组发作频率、硝酸甘油用量、持续时间少于治疗前,且观察组少于对照组(P<0.05);两组CO、LVEF、SV均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组ST段压低幅度、ST段压低次数均低于治疗前,且观察组低于对照组(P<0.05);两组血清Angptls2、ox-LDL、CTRP1水平低于治疗前,且观察组低于对照组(P<0.05)。两组不良反应发生情况比较,差异无统计学意义(P>0.05)。【结论】丹参川芎嗪注射液联合曲美他嗪治疗UAP临床疗效较好,有助于减轻患者症状,改善心功能,安全性高。
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何照国
邹洋
关键词 心绞痛,不稳定型/药物疗法丹参川芎嗪注射液/治疗应用曲美他嗪/治疗应用心电描记术    
Abstract:【Objective】To explore the effects of Danshen Chuanxiongqin Injection combined with Trimetazidine on electrocardiogram and cardiac function in patients with unstable angina pectoris (UAP).【Methods】A retrospective analysis was conducted on the clinical data of 106 UAP patients admitted to our hospital from January 2021 to May 2023. According to different treatment methods, they were divided into a control group and an observation group, with 53 cases in each group. The control group was treated with trimetazidine, while the observation group was treated with Danshen Chuanxiongqin Injection+trimetazidine. We compared between two groups in terms of the clinical efficacy, seizure frequency, nitroglycerin dosage, duration, cardiac function [cardiac output (CO), left ventricular ejection fraction (LVEF), stroke output (SV)], and electrocardiogram changes [ST segment depression amplitude], ST segment depression frequency, serum biochemical indicators, angiopoietin like protein 2 (Angptls2), oxidized low-density lipoprotein (ox-LDL),C1q tumor necrosis factor related protein 1 (CTRP1) and occurrence of adverse reactions.【Results】The effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the seizure frequency, nitroglycerin dosage, and duration of the two groups were lower than before treatment, and the observation group was lower than the control group (P<0.05); CO, LVEF and SV of two sets were both higher than those before treatment, and the observation group was higher than the control group, with a statistically significant difference (P<0.05); The ST segment depression amplitude and the number of ST segment depressions of two groups were lower than those before treatment, and the observation group was lower than the control group (P<0.05); The levels of Serum Angptls2, ox-LDL and CTRP1 of the two groups were lower than those before treatment, and the observation group was lower than the control group (P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】The combination of Danshen Chuanxiongqin Injection and Trimetazidine has a good clinical efficacy in the treatment of UAP, which helps to alleviate patient symptoms, improve heart function, and has high safety.
Key wordsAngina, Unstable/DT    Danshen Chuanxiongqin Zhusheye/TU    Trimetazidine/TU    Electrocardiography
收稿日期: 2023-08-24     
中图分类号:  R541.42  
引用本文:   
何照国, 邹洋. 丹参川芎嗪注射液联合曲美他嗪对不稳定型心绞痛患者心电图、心功能的影响[J]. 医学临床研究, 2024, 41(5): 747-749.
HE Zhaoguo, ZOU Yang. The Effects of Danshen Chuanxiongqin Injection Combined with Trimetazidine on Electrocardiogram and Cardiac Function Levels in Patients with Unstable Angina Pectoris. JOURNAL OF CLINICAL RESEARCH, 2024, 41(5): 747-749.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.05.029     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I5/747
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