The Effect of Different Doses of Dexmedetomidine on Postoperative Cognitive Function and Inflammatory Cytokine Levels in Elderly Patients Undergoing Laparoscopic Gastric Cancer Resection
FU Hongbo, YANG Li
Department of Anesthesiology, Affiliated Hospital of Xizang Minzu University, Xianyang Shaanxi 712082
Abstract：【Objective】 To explore the effects of different doses of dexmedetomidine (Dex) on postoperative cognitive function and inflammatory cytokine levels in elderly patients undergoing laparoscopic gastric cancer resection (LAGRP).【Methods】 A total of 128 elderly patients scheduled for LAGRP were randomly divided into a control group (C group) and three different doses of Dex groups (D1 group,D2 group,D3 group), with 32 patients in each group. All patients received general anesthesia. During anesthesia maintenance, the D1 group, D2 group, and D3 group were given dexmedetomidine via intravenous infusion at doses of 0.2 μg/(kg?h), 0.5 μg/(kg?h), and 0.6 μg/(kg?h), respectively, while the C group received an equal volume of saline. The perioperative indicators, pain severity, cognitive function, inflammatory cytokine levels, and incidence of adverse reactions were compared among the four groups.【Results】 There were no significant differences in surgery duration, intraoperative blood loss, or length of hospital stay among the four groups (P>0.05). The D3 group had a longer awakening time compared to the C group, D1 group, and D2 group (P<0.05). Postoperative 48-hour Visual Analog Scale (VAS) pain scores were lower in the D1 group, D2 group, and D3 group compared to the C group (P<0.05). The Mini-Mental State Examination (MMSE) scores on postoperative days 1 and 3 were higher in the D1 group, D2 group, and D3 group compared to the C group (P<0.05). C-reactive protein (CRP) and procalcitonin (PCT) levels on postoperative days 1 and 3 were lower in the D1 group, D2 group, and D3 group compared to the C group (P<0.05). There were no significant differences in the total incidence of adverse reactions among the four groups (P>0.05).【Conclusion】 Dexmedetomidine at different doses can improve postoperative cognitive function and inhibit inflammatory responses in elderly patients undergoing LAGRP, with good safety. A dose of 0.5 μg/(kg?h) showed the best overall effect.
付宏博, 杨莉. 不同剂量右美托咪定对老年腹腔镜胃癌根治术患者术后认知功能及炎症因子水平的影响[J]. 医学临床研究, 2024, 41(12): 1899-1902.
FU Hongbo, YANG Li. The Effect of Different Doses of Dexmedetomidine on Postoperative Cognitive Function and Inflammatory Cytokine Levels in Elderly Patients Undergoing Laparoscopic Gastric Cancer Resection. JOURNAL OF CLINICAL RESEARCH, 2024, 41(12): 1899-1902.
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2024, Vol. 41 
