Abstract：【Objective】 To investigate the correlation between interleukin-8 (IL-8),soluble programmed death ligand 1 (sPD-L1),T cell subpopulation levels,and intracranial infection after intracranial tumor resection. 【Methods】 A total of 126 patients who underwent intracranial tumor resection in our hospital from July 2019 to September 2021 were selected and divided into an infected group (n=84) and an uninfected group (n=42) based on whether infection occurred 7 days after surgery. We compared the levels of sPD-L1,IL-8,T cell subpopulations,neurological impairment indicators,and oxidative stress indicators between two groups and patients with different infection types. We used Spearman correlation coefficient to analyze the correlation between sPD-L1,IL-8,T cell subpopulations,intracranial infection types,neurological impairment indicators,and oxidative stress indicators. 【Results】 Compared with the uninfected group 7 days after surgery,the infected group had higher levels of sPD-L1,IL-8,and CD8+ in serum at the time of confirmed infection,while lower levels of CD3+ and CD4+ were observed,with statistically significant differences (P<0.05). The comparison of serum sPD-L1,IL-8,and CD8+ levels during infection was confirmed:bacterial intracranial infection group>tuberculous intracranial infection group>viral intracranial infection group (P<0.05); Comparison of CD3+ and CD4+ levels:the Bacterial intracranial infection group < the tuberculous intracranial infection group < the viral intracranial infection group (P<0.05). Comparison of serum S-100β,NSE,and SOD levels during infection:bacterial intracranial infection>tuberculous intracranial infection>viral intracranial infection (P<0.05) was diagnosed; MDA levels were compared:bacterial intracranial infection < tuberculosis intracranial infection < viral intracranial infection (P<0.05). The serum levels of sPD-L1,IL-8,and CD8+ were positively correlated with S-100β,NSE,and SOD (P<0.05),and negatively correlated with MDA (P<0.05); The levels of CD3+ and CD4+ were negatively correlated with S-100β,NSE,and SOD (P<0.05),and positively correlated with MDA (P<0.05).【Conclusion】 The serum levels of sPD-L1,IL-8,and T cell subpopulations after intracranial tumor resection are closely related to the occurrence of intracranial infection,which can provide reference for early clinical diagnosis of infection types and evaluation of the condition,and is conducive to formulating treatment plans.
2023, Vol. 40 
