Abstract：【Objective】To investigate the relationship between serum levels of bone morphogenetic protein 6 (BMP6) and transforming growth factor beta-1 (TGF-β1) in patients with coronary heart disease (CHD). 【Methods】90 patients with CHD diagnosed and treated in our hospital from December 2017 to October 2020 were selected as CHD group, and 90 healthy persons in physical examination in the same period were selected as healthy group. Serum BMP6, creatine kinase MB (CK-MB), TGF-β1, cardiac troponin I (cTnI) were compared between the two groups; the relationship between serum BMP6, TGF-β1 levels and CK-MB, cTnI in CHD patients, and the correlation between serum BMP6 levels and TGF-β1 were analyzed; the serum BMP6 and TGF-β1 levels in patients with CHD with different diseased branches were compared; the value of serum BMP6 and TGF-β1 levels in the diagnosis of CHD were evaluated. 【Results】Serum CK-MB, BMP6 and cTnI levels in CHD group were higher than those in healthy group (P<0.05), and TGF-β1 levels were lower than healthy group (P<0.05); Serum BMP6 levels in CHD patients were positively correlated with CK-MB and cTnI (P<0.05), and negatively correlated with TGF-β1 (P<0.05); serum TGF-β1 levels in CHD patients were negatively correlated with CK-MB and cTnI (P<0.05); with the increase of the number of coronary artery lesions (aggravation), the level of serum BMP6 increased gradually (P<0.05), and the level of TGF-β1 gradually decreased (P<0.05); there was a negative correlation between serum BMP6 level and TGF-β1 in CHD patients (P<0.05); the area under the curve (AUC) of serum BMP6 and TGF-β1 in the diagnosis of CHD was 0.899 and 0.845, the cut-off value was 35.36 pg/mL and 104.99 pg/mL, respectively, the both sensitivity was 88.9%, and specificity was 77.8% and 72.2% respectively; the AUC of the combined diagnosis was 0.939, the corresponding sensitivity was 86.7%, and the specificity was 90.0%.【Conclusion】The level of serum BMP6 in CHD patients is increased, and the level of TGF-β1 is decreased, they are related to the severity of coronary artery disease. The combination of BMP6 and TGF-β1 can improve the diagnostic value of CHD and contribute to the clinical diagnosis of CHD.
廖占玲, 安国印, 吴晶晶, 陈润祥. 冠心病患者血清BMP6、TGF-β1水平与冠状动脉病变程度的相关性[J]. 医学临床研究, 2022, 39(3): 435-438.
LIAO Zhan-ling, AN Guo-yin, WU Jing-jing, et al. Correlation Between Serum Levels of BMP6, TGF-β1 and Severity of Coronary Artery Disease in Patients with Coronary Heart Disease. JOURNAL OF CLINICAL RESEARCH, 2022, 39(3): 435-438.
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2022, Vol. 39 
