Abstract：【Objective】To investigate the efficacy of L-carnitine combined with furosemide in the treatment of heart failure patients with chronic kidney disease(CKD)undergoing hemodiafiltration (HDF). 【Methods】A total of 120 CKD patients with HDF, who complicated with heart failure, were randomly divided into two groups. The control group received proper HDF and conventional anti-heart failure treatment. While the observation group received intravenous injection of L-carnitine and furosemide on the basis of treatment in the control group. Patients in the two groups were treated continuously for 12 weeks . Cardiac function indicators, angiotensin (Ang Ⅱ), plasma renin (PRA), aldosterone (ALD) and N-terminal pro-brain natriuretic peptide (NT-proBNP), 6 min walking distance(6MWT) and incidence of adverse reactions were compared between two groups. 【Results】After treatment, the total effective rate of the observation group was 91.67% (55/60), which was significantly higher than that of the control group 75.00% (45/60); the difference was statistically significant (P<0.05). In both groups, the levels of AngⅡ, PRA, ALD, NT-proBNP, cardiac index (CI), LVEDD, LVPWT and IVST after treatment were significantly lower than those before treatment; While the levels of LVEF and 6MWT were significantly higher than those before treatment (P<0.05). The improvement level of the observation group was more obvious than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】The application of L-carnitine combined with furosemide in the treatment of heart failure patients with CKD undergoing HDF has good efficacy, which shows significant improvement of patients' cardiac function and 6MWT. It is safe and worthy of clinical application.
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2019, Vol. 36 
