Abstract：【Objective】To investigate the relationship of monocyte/high-density lipoprotein ratio (MHR) with chronic kidney disease (CKD) stage and predictive value of cardiovascular events in patients with CKD. 【Methods】A total of 180 patients with non-hemodialysis CKD (stage 3 to 5) in our hospital were collected for the study. According to the level of glomerular rate filtration (GFR), patients were divided into group A (CKD stage 3, n=65 cases), group B (CKD stage 4, n=55 cases) and group C (CKD stage 5, n=60 cases). They further were divided into the cardiovascular event group (n=75 cases) and non-cardiovascular event group (n=105 cases) depending on cardiovascular events occurred within 6 months of follow-up. There were 40 healthy volunteers enrolled in the control group. Blood routine, high-density lipoprotein (HDL), creatinine, urea nitrogen, NT-proBNP, GFR and MHR were recorded and compared among groups. The relationship of MHR with GFR and NT-proBNP was analyzed by Spearman correlation analysis. The predictive value of MHR and NT-proBNP on cardiovascular events in patients with CKD was analyzed by drawing the ROC curve. 【Results】The levels of MHR and NT-proBNP increased gradually with the increase of CKD stages, showing that the level of group C> group B> group A> the control group (P<0.05).The levels of MHR and NT-proBNP in patients with cardiovascular events were significantly higher than those in non-cardiovascular events (P<0.05). In patients with CKD, MHR was negatively correlated with GFR (P<0.01), while MHR was positively correlated with NT-proBNP (P<0.01).The area under the ROC curve for diagnosis of cardiovascular events by MHR and NT-proBNP in CDK patients were 0.958 and 0.932, respectively. The diagnostic sensitivities were 92% and 86.7%, respectively, and the specificity were 92.6% and 89.6%, respectively. 【Conclusion】There is a close relationship between the occurrence of cardiovascular events and inflammatory state in CKD patients. MHR is superior to traditional indicators in predicting the occurrence of cardiovascular events in CKD patients.
杨曦, 华雪莲. 单核细胞/高密度脂蛋白比值对慢性肾脏病心血管事件的预测价值研究[J]. 医学临床研究, 2019, 36(11): 2157-2159.
YANG Xi, HUA Xue-lian. Predictive Value of Monocyte/High-density Lipoprotein Ratio for Cardiovascular Events in Patients with Chronic Kidney Disease. JOURNAL OF CLINICAL RESEARCH, 2019, 36(11): 2157-2159.
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