CA125、CEA与BNP联合检测在左心衰竭早期诊断中的临床价值

doi:10.3969/j.issn.1671-7171.2026.07.002

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摘要 【目的】探讨糖类抗原125(CA125)、癌胚抗原(CEA)和脑钠肽(BNP)联合检测在左心衰竭(LHF)早期诊断中的临床价值。【方法】选取2021年1月至2024年6月本院收治的78例LHF早期患者作为观察组,选取同期在本院体检的85例健康者作为对照组。比较两组CA125、CEA、 BNP水平和心功能相关指标[左室射血分数(LVEF)、左室舒张末容积(LVEDV)],采用Pearson相关分析各指标的相关性。采用受试者操作特征(ROC)曲线评估CA125、CEA、 BNP在LHF早期诊断中的效能。【结果】观察组CA125、CEA和BNP水平高于对照组(P<0.05)。观察组LVEF明显低于对照组(P<0.05),LVEDV显著高于对照组(P<0.05)。Pearson相关性分析显示,CA125、CEA和BNP与LVEF呈负相关(P<0.05),与LVEDV呈正相关(P<0.05)。ROC曲线表明, CA125、CEA、 BNP联合检测的诊断效能最高,其曲线下面积为0.979,敏感度为96.2%,特异度为96.5%。【结论】CA125、CEA和BNP联合检测在LHF早期诊断中具有重要的临床价值,可为临床早期干预提供依据。

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	韩开武
	史变
	吕慧梅

关键词 ：心力衰竭, CA125抗原, 癌胚抗原, 利尿钠肽,脑

Abstract：【Objective】 To explore the clinical application value of combined detection of carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA) and brain natriuretic peptide (BNP) for early identification of left heart failure (LHF). 【Methods】 A total of 78 patients with early LHF admitted to the hospital from January 2021 to June 2024 were enrolled as the observation group, and 85 healthy volunteers undergoing physical examination during the same period were selected as the control group. Levels of CA125, CEA, BNP and cardiac function indicators including left ventricular ejection fraction (LVEF) and left ventricular end-diastolic volume (LVEDV) were compared between the two groups. Pearson correlation analysis was used to analyze the correlation among above indexes. Receiver operating characteristic (ROC) curve was adopted to evaluate the diagnostic efficacy of single and combined detection of CA125, CEA and BNP in early LHF. 【Results】 The levels of CA125, CEA and BNP in the observation group were significantly higher than those in the control group (P<0.05). LVEF in the observation group was obviously lower, while LVEDV was markedly higher than that in the control group (P<0.05). Pearson correlation analysis showed CA125, CEA and BNP were negatively correlated with LVEF and positively correlated with LVEDV (P<0.05). ROC curve analysis revealed combined detection of the three indexes presented the optimal diagnostic efficiency, with an area under the curve of 0.979, a sensitivity of 96.2% and a specificity of 96.5%. 【Conclusion】 The combined detection of CA125, CEA and BNP possesses important clinical significance for early diagnosis of LHF, and it can provide reference basis for clinical early intervention.

Key words： Heart Failure CA125 Antigen Carcinoembryonic Antigen Natriuretic Peptide,Brain

收稿日期: 2025-02-25

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R541.61

引用本文:

韩开武, 史变, 吕慧梅. CA125、CEA与BNP联合检测在左心衰竭早期诊断中的临床价值[J]. 医学临床研究, 2026, 43(7): 1061-1063.
HAN Kaiwu, SHI Bian, LYU Huimei. Clinical Value of Combined Detection of CA125, CEA and BNP in Early Diagnosis of Left Heart Failure. JOURNAL OF CLINICAL RESEARCH, 2026, 43(7): 1061-1063.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2026.07.002 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2026/V43/I7/1061

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