Abstract：【Objective】 To investigate the clinical efficacy and safety of a controlled circulation-based low central venous pressure (LCVP) technique in hepatectomy.【Methods】 A total of 86 patients undergoing hepatectomy were randomly divided into an observation group and a control group, with 43 patients in each group. The control group received conventional anesthesia management, while the observation group was managed with the controlled circulation-based LCVP technique. Surgical variables were compared between the two groups. Hemodynamic parameters-mean arterial pressure (MAP) and heart rate (HR) were recorded before anesthesia induction (T0), 1 min after tracheal intubation (T1), 1 min after the start of hepatic parenchymal transection (T2), and at the end of surgery. Liver function indices-alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBil) were measured preoperatively and 7 days postoperatively. Safety outcomes were also assessed. 【Results】 Intraoperative blood loss, fluid infusion volume, urine output, and blood transfusion rate in the observation group were all lower than those in the control group, and the operative time in the observation group was shorter (P<0.05). At T1, T2, and at the end of surgery, MAP and HR in the observation group were significantly lower than those in the control group (P<0.05). Seven days after surgery, levels of ALT, AST, and TBil were significantly lower in the observation group than in the control group (P<0.05). The overall incidence of adverse reactions was also lower in the observation group than that in the control group (P<0.05).【Conclusion】 The controlled circulation-based LCVP technique can effectively reduce intraoperative blood loss, fluid infusion volume, and urine output, decrease transfusion requirements, lower MAP and HR, shorten operative time, and promote postoperative recovery of liver function in patients undergoing hepatectomy, with good safety. This technique is worthy of clinical application and promotion.
2026, Vol. 43 
