Influence of Initiating the PPOS Protocol at Different Menstrual Cycles on Outcome of Assisted Reproduction in Patients with Diminished Ovarian Reserve
XING Jingjing, MA Xinxiang, LIU Min, et al
Department of Reproductive Genetics, Zhengzhou Maternal and Child Health Hospital, Zhengzhou Henan 450000
Abstract：【Objective】To explore the impact of different menstrual cycle initiation of high progesterone state ovulation induction (progesterone primed ovarian stimulation, PPOS) on the pregnancy outcomes of patients with diminished ovarian reserve (DOR). 【Methods】A retrospective analysis was conducted on the clinical data of 216 DOR patients who underwent PPOS treatment in our hospital from January 2018 to December 2023. The patients were divided into the follicular phase initiation group (Group A, n=114) and the luteal phase initiation group (Group B, n=102) based on the initiation timing. The number of retrieved oocytes, the rate of metaphase Ⅱ(MⅡ) oocytes, the number of available embryos, the rate of high-quality embryos on day 3 (D3) of cleavage, clinical pregnancy rate, live birth rate, total dose of gonadotropin (Gn) drugs, the duration of Gn drug use, cycle cancellation rate, and the incidence of ovarian hyperstimulation syndrome (OHSS) were compared between the two groups. 【Results】The number of retrieved oocytes and the MⅡ oocyte rate in Group A were higher than those in the Group B, with statistically significant differences (P<0.05). There were no statistically significant differences in the number of available embryos, the rate of high-quality embryos on D3, clinical pregnancy rate, live birth rate, cycle cancellation rate, and the incidence of OHSS between the two groups (P>0.05). The total dose of Gn drugs and the duration of Gn drug use in Group A were less than those in Group B, with statistically significant differences (P<0.05). 【Conclusion】The follicular phase initiation PPOS protocol can increase the number of retrieved oocytes and the rate of mature oocytes in DOR patients, and can reduce the dose of ovulation induction drugs and the duration of ovulation induction, but it does not significantly improve the clinical pregnancy rate and live birth rate.
邢晶晶, 马新想, 刘敏, 张富青. 不同月经周期启动PPOS方案对卵巢储备功能减退患者助孕结局的影响[J]. 医学临床研究, 2025, 42(11): 1921-1923.
XING Jingjing, MA Xinxiang, LIU Min, et al. Influence of Initiating the PPOS Protocol at Different Menstrual Cycles on Outcome of Assisted Reproduction in Patients with Diminished Ovarian Reserve. JOURNAL OF CLINICAL RESEARCH, 2025, 42(11): 1921-1923.
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2025, Vol. 42 
