慢性丙型肝炎患者血管内皮功能障碍标志物水平及与脑血管反应性的相关性

doi:10.3969/j.issn.1671-7171.2025.08.025

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摘要【目的】探讨慢性丙型肝炎(CHC)患者血管内皮功能障碍标志物[细胞间黏附因子1(ICAM-1)、血管细胞黏附因子1(VCAM-1)、血管内皮生长因子A(VEGF-A)]水平及与脑血管反应性的相关性。【方法】本院收治的50例CHC患者为肝炎组,另选择同期30例健康献血志愿者为对照组。比较两组ICAM-1、VCAM-1、VEGF-A水平及屏气指数(BHI),分析ICAM-1、VCAM-1、VEGF-A水平与脑血管反应性的相关性。【结果】肝炎组患者ICAM-1、VCAM-1均高于对照组(P<0.05),VEGF-A、BHI均低于对照组(P<0.05)。Pearson相关性分析结果显示:肝炎组ICAM-1、VCAM-1与BHI呈显著负相关(r=-0.584、-0.670,均P<0.05),VEGF-A与BHI水平呈显著正相关(r=0.604,P<0.05);对照组ICAM-1、VCAM-1及VEGF-A水平与BHI无相关性(均P>0.05)。【结论】CHC患者存在显著的血管内皮功能障碍,其血清ICAM-1和VCAM-1水平升高,VEGF-A水平降低,并与脑血管反应性指标BHI显著相关。

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	卢瞧
	杨瀚
	刘剑英

关键词 ：丙型肝炎,慢性, 内皮,血管, 生物标记

Abstract：【Objective】 To investigate the levels of serum biomarkers of endothelial dysfunction-intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and vascular endothelial growth factor A (VEGF-A) in patients with chronic hepatitis C (CHC), and their correlation with cerebrovascular reactivity.【Methods】 A total of 50 CHC patients treated in our hospital were included in the hepatitis group, while 30 healthy blood donors were selected as the control group. Levels of ICAM-1, VCAM-1, VEGF-A, and breath-holding index (BHI) were compared between the two groups. Pearson correlation analysis was used to evaluate the association of ICAM-1, VCAM-1 and VEGF-A levels with cerebrovascular reactivity.【Results】 Levels of ICAM-1 and VCAM-1 were significantly higher in the hepatitis group than in the control group (P<0.05), while VEGF-A and BHI in the hepatitis group were significantly lower than those in the control group (P<0.05). Pearson correlation analysis showed that ICAM-1 and VCAM-1 were significantly negatively correlated with BHI in the hepatitis group (r=-0.584 and -0.670, respectively; both P<0.05), whereas VEGF-A was significantly positively correlated with BHI (r=0.604, P<0.05). In the control group, no significant correlation was observed between BHI and levels of ICAM-1, VCAM-1 andVEGF-A (all P>0.05).【Conclusion】 Patients with CHC have significant endothelial dysfunction showing increased serum ICAM-1 and VCAM-1 levels and decreased VEGF-A level, which are significantly correlated with cerebrovascular reactivity as measured by BHI.

Key words： Hepatitis C, Chronic Endothelium, Vascular Biomarkers

收稿日期: 2025-04-10

中图分类号:

R512.63

引用本文:

卢瞧, 杨瀚, 刘剑英. 慢性丙型肝炎患者血管内皮功能障碍标志物水平及与脑血管反应性的相关性[J]. 医学临床研究, 2025, 42(8): 1382-1384.
LU Qiao, YANG Han, LIU Jianying. Correlation of Serum Biomarker Levels of Endothelial Dysfunction with Cerebrovascular Reactivity in Patients with Chronic Hepatitis C. JOURNAL OF CLINICAL RESEARCH, 2025, 42(8): 1382-1384.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.08.025 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I8/1382

[1] 徐聪慧, 吕婉婷, 郭佳欢, 等. 影响慢性丙型肝炎抗病毒治疗因素的研究现状[J].中华实验和临床病毒学杂志, 2024, 38(6):717-721.
[2] 刘伶, 王栋, 贺松, 等. 乙丙型肝炎病毒双重感染外周血淋巴细胞亚群表达[J].中华医院感染学杂志, 2024, 34(14):2099.
[3] CLYNE A M. Endothelial response to glucose: dysfunction, metabolism, and transport[J].Biochem Soc Trans,2021, 49(1):313-325.
[4] INCALZA M A, D'ORIA R, NATALICCHIO A, et al. Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases[J].Vascul Pharmacol,2018, 100:1-19.
[5] MCDONALD M J, MARSH M L, FEARS S D, et al. Impact of acute sleep restriction on cerebrovascular reactivity and neurovascular coupling in young men and women[J].J Appl Physiol (1985),2025, 138(1):282-288.
[6] ZVOLANEK K M, MOORE J E, JARVIS K, et al. Macrovascular blood flow and microvascular cerebrovascular reactivity are regionally coupled in adolescence[J].J Cereb Blood Flow Metab,2025, 45(4):746-764.
[7] 中华医学会肝病学分会, 中华医学会感染病学分会. 丙型肝炎防治指南(2022年版)[J].中华传染病杂志, 2023, 41(1):29-46.
[8] JANG W B, RETHINESEARAN V K, KWON S M. Targeting mitochondrial dysfunction to prevent endothelial dysfunction and atherosclerosis in diabetes: Focus on the novel uncoupler BAM15[J].Int J Mol Sci,2025, 26(10):4603-4613.
[9] SOLUND C, HASBAK P, KNUDSEN A, et al. Myocardial perfusion reserve in patients with chronic hepatitis C before and after direct-acting antiviral treatment-a pilot study[J].Clin Physiol Funct Imaging,2022, 42(6):389-395.
[10] WAHSH E A, HUSSEIN A K, GOMAA A A, et al. Real life Egyptian experience of daclatasvir plus sofosbuvir with ribavirin in baïve difficult to treat HCV patients[J].Infect Disord Drug Targets,2020, 20(1):43-48.
[11] RAMDAN H K, MEGHEZEL E M, ABDEL-MALEK M O, et al. Correlation between vascular endothelial growth factor and long-term occurrence of HCV-related hepatocellular carcinoma after treatment with direct-acting antivirals[J].Cancer Invest,2021, 39(8):653-660.
[12] KAPOOR A, JANG J Y, ENGSTROM A C, et al. Elevated vascular endothelial growth factor a is associated with disruption of default network connectivity in older adults[J].Brain Imaging Behav,2025, 19(2):379-383.
[13] ARSLAN G D, OLGUN A, OZCAN D, et al. Assessment of cerebral vasomotor reactivity in patients with primary open-angle glaucoma and ocular hypertension using the breath-holding index[J].J Glaucoma,2021, 30(2):157-163.