甘油三酯与胱抑素C比值联合UNAG检测对糖尿病肾病早期的诊断价值

doi:10.3969/j.issn.1671-7171.2025.07.025

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1228 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要【目的】探讨甘油三酯(TG)与胱抑素C(cys C)比值(TG/cys C)联合尿N-乙酰-β-D氨基葡萄糖苷酶(UNAG)诊断早期糖尿病肾病(DN)的效能。【方法】182例2型糖尿病(T2DM)患者,其中伴DN患者69例(DN组),其余113例为非DN组。比较两组患者的基本资料,采用Logistic回归分析影响早期DN的诊断因素,采用受试者工作特征(ROC)曲线分析相关指标诊断DN的价值,对比不同病情DN患者UNAG、TG/cys C水平。【结果】 Logistic多因素回归分析显示:血肌酐、UNAG、TG/cys C是影响早期DN诊断的因素(均P<0.05)。ROC曲线结果显示,UNAG、TG/cys C二者联合诊断DN的灵敏度、特异度、曲线下面积(AUC)均高于单一指标检测(均P<0.05)。临床DN组的UNAG水平高于早期DN组,TG/cys C低于早期DN组(均P<0.05)。【结论】 TG/cys C联合UNAG检测可提高对早期DN的诊断效能。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	张伟伟
	常慧
	史志鹏

关键词 ：糖尿病肾病, 甘油三酯类, 半胱氨酸蛋白酶抑制物C

Abstract：【Objective】 To investigate the diagnostic value of triglyceride (TG)/cystatin C (cys C) ratio combined with urine N-acetyl-β-D-glucosaminidase (UNAG) for the early diagnosis of diabetic nephropathy (DN).【Methods】 A total of 182 patients with Type 2 diabetes mellitus (T2DM) were included in this study, with 69 cases in the DN group and 113 cases in the non-DN group. The baseline data were compared between the two groups. Logistic regression was used to identify factors affecting the early diagnosis of DN, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic value of related indicators. The UNAG and TG/cys C ratio were also analyzed in patients with different stages of DN.【Results】 Logistic multivariate regression analysis revealed that serum creatinine, UNAG, and TG/cys C were influencing factors for the early diagnosis of DN (all P<0.05). The ROC curve demonstrated that the combination of UNAG and TG/cys C had higher diagnostic sensitivity, specificity, and area under the curve (AUC) than each indicator used individually (all P<0.05). The UNAG level was higher in the clinical DN group than in the early DN group, while the TG/cys C ratio in the clinical DN group was lower in the clinical DN group (both P<0.05).【Conclusion】 The combination of the TG/cys C ratio and UNAG can improve the diagnostic accuracy for diabetic nephropathy.

Key words： Diabetic Nephropathies Triglycerides Cystatin C

收稿日期: 2025-03-26

中图分类号:

R587.24

引用本文:

张伟伟, 常慧, 史志鹏. 甘油三酯与胱抑素C比值联合UNAG检测对糖尿病肾病早期的诊断价值[J]. 医学临床研究, 2025, 42(7): 1192-1194.
ZHANG Weiwei, CHANG Hui, SHI Zhipeng. Diagnostic Value of Serum Triglyceride/Cystatin C Ratio Combined with Urine N-Acetyl-β-D-Glucosaminidase Detection for Diabetic Nephropathy at an Early Stage. JOURNAL OF CLINICAL RESEARCH, 2025, 42(7): 1192-1194.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.07.025 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I7/1192

[1] BARUTTA F, BELLINI S, GRUDEN G. Mechanisms of podocyte injury and implications for diabetic nephropathy[J].Clin Sci (Lond),2022,136(7):493-520.
[2] WANG S M, ZHANG X Y, WANG Q L, et al. Histone modification in podocyte injury of diabetic nephropathy[J].J Mol Med (Berl),2022, 100(10):1373-1386.
[3] PEREIRA P R, CARRAGETA D F, OLIVEIRA P F, et al. Metabolomics as a tool for the early diagnosis and prognosis of diabetic kidney disease[J].Med Res Rev,2022, 42(4):1518-1544.
[4] WEI J, WANG B, SHEN F J, et al. Diagnostic value of triglyceride and cystatin C ratio in diabetic kidney disease: a retrospective and prospective cohort study based on renal biopsy[J].BMC Nephrol,2022, 23(1):270-273.
[5] LIN Z H, DAI S F, ZHAO J N, et al. Application of urinary N-acetyl-β-D-glucosaminidase combined with serum retinol-binding protein in early detection of diabetic nephropathy[J].World J Diabetes,2023, 14(6):883-891.
[6] LI X, LU L H, HOU W T, et al. Epigenetics in the pathogenesis of diabetic nephropathy[J].Acta Biochim Biophys Sin,2022, 54(2):163-172.
[7] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版)[J].中华糖尿病杂志, 2021, 13(4):315-409.
[8] 中华医学会肾脏病学分会专家组. 糖尿病肾脏疾病临床诊疗中国指南[J].中华肾脏病杂志, 2021, 37(3):255-304.
[9] KIM H K, LEE M, LEE Y H, et al. Renal tubular damage marker, urinary N-acetyl-β-D-Glucosaminidase, as a predictive marker of hepatic fibrosis in type 2 diabetes mellitus[J].Diabetes Metab J,2022, 46(1):104-116.
[10] 杨琼, 戴霞, 楼青青, 等. 壮族2型糖尿病患者空腹甘油三酯变异性与糖尿病肾病的关系及影响因素分析[J].现代预防医学, 2023, 50(3):391-395.
[11] ZHAO P, LI N, LIN L,et al. Correlation between serum cystatin C level and renal microvascular perfusion assessed by contrast-enhanced ultrasound in patients with diabetic kidney disease[J].Ren Fail,2022, 44(1):1732-1740.
[12] 魏晶, 周冬梅, 李培培, 等. 甘油三酯/胱抑素C比值联合3项指标对糖尿病肾病的诊断价值[J].中华检验医学杂志, 2022, 45(1):58-64.
[13] 彭健韫, 金菊, 项美娟, 等. 血清及尿液生化指标对糖尿病肾病的早期诊断价值分析[J].浙江医学, 2022, 44(13):1397-1401.
[14] BÍRÓ E,SZEGEDI I, KISS C, et al. The role of urinary N-acetyl-β-D-glucosaminidase in early detection of acute kidney injury among pediatric patients with neoplastic disorders in a retrospective study[J].BMC Pediatr,2022, 22(1):429.