Abstract：【Objective】 To explore the clinical efficacy of transarterial chemoembolization (TACE) combined with targeted immunotherapy in the treatment of primary liver cancer.【Methods】 A total of 80 patients with primary liver cancer were divided into the control group (37 cases, treated with TACE alone) and the observation group (43 cases, treated with TACE combined with targeted immunotherapy) based on different treatment modalities. The clinical efficacy, changes in liver function indicators, incidence of complications, and survival outcomes were compared between the two groups.【Results】 The objective response rate and disease control rate in the observation group were higher than those in the control group (P<0.05). After treatment, liver function in both groups improved compared to pre-treatment levels, with the observation group showing a more significant improvement than the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). The 1-year survival rate, overall survival, and progression-free survival in the observation group were superior to those in the control group (P<0.05).【Conclusion】 TACE combined with targeted immunotherapy can improve the objective response rate and disease control rate, enhance liver function, and prolong survival in patients with primary liver cancer, demonstrating significant clinical value.
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2025, Vol. 42 
