Abstract：【Objective】To explore the changing characteristics of vitamin D status and parathyroid hormone (PTH) level in girls with central precocious puberty (CPP). 【Methods】A total of 81 girls with CPP who visited our hospital from January 2022 to June 2024 were selected as the observation group, and 81 healthy girls who underwent physical examinations in our hospital during the same period were selected as the control group. The growth rates and the levels of blood calcium, blood phosphorus, 25-hydroxyvitamin D[25(OH)D], and PTH of the two groups were compared. The laboratory indicators of different seasons and different vitamin D status of the two groups were compared. The clinical data of CPP girls with different vitamin D status were compared as well. 【Results】There was no statistically significant difference in the levels of blood calcium, blood phosphorus and blood 25(OH)D between the two groups (P>0.05). The growth rate and blood PTH level in the observation group were both higher than those in the control group (P<0.05). The PTH levels in the two groups in summer were significantly lower than those in the other three seasons (P<0.05), while the 25(OH)D levels of the two groups in summer were significantly higher than those in the other three seasons (P<0.05). The PTH level of the observation group in spring, summer, autumn and winter was significantly higher than that of the control group (P<0.05). There was no statistically significant difference in the levels of calcium and phosphorus between the two groups with different vitamin D status (P>0.05). The PTH levels of children with normal vitamin D in both groups were lower than those of children with vitamin D deficiency and insufficient vitamin D (P<0.05). The PTH levels of children in the observation group with different vitamin D status were all higher than those in the control group (P<0.05). 【Conclusion】The vitamin D level of female children with CPP was comparable to that of healthy girl volunteers, suggesting that there was no correlation between vitamin D status and the occurrence of CPP. The PTH level of children with CPP was significantly increased.
徐子惠. 中枢性性早熟女童的维生素D状态和甲状旁腺激素水平的变化特点*[J]. 医学临床研究, 2025, 42(5): 754-757.
XU Zihui. The Characteristics of Vitamin D Status and Parathyroid Hormone Level Changes in Girls with Central Precocious Puberty. JOURNAL OF CLINICAL RESEARCH, 2025, 42(5): 754-757.
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2025, Vol. 42 
