脐血瘦素、IGFBP-3水平与妊娠期糖尿病孕妇分娩巨大儿的相关性分析

doi:10.3969/j.issn.1671-7171.2025.04.018

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摘要【目的】探讨脐血瘦素、胰岛素样生长因子结合蛋白3(IGFBP-3)水平与妊娠期糖尿病(GDM)孕妇分娩巨大儿的相关性。【方法】选取2020年4月至2023年6月在本院分娩的312例GDM孕妇,根据新生儿出生体重将孕妇分为A组(巨大儿,新生儿出生体重≥4 kg)和B组(非巨大儿,新生儿出生体重正常或低于正常体重),比较两组分娩前脐血瘦素、IGFBP-3水平,分析GDM孕妇娩出巨大儿的影响因素,探讨脐血瘦素、IGFBP-3与GDM孕妇娩出巨大儿的相关性及脐血瘦素、IGFBP-3对GDM孕妇娩出巨大儿的预测价值。【结果】A组IGFBP-3、脐血瘦素、空腹血糖水平均高于B组(P<0.05)。二元 Logistic回归分析结果显示:空腹血糖、脐血瘦素、IGFBP-3水平较高是GDM孕妇娩出巨大儿的危险因素(P<0.05)。受试者工作特征(ROC)曲线分析结果显示:脐血瘦素、IGFBP-3、空腹血糖联合预测GDM孕妇娩出巨大儿的曲线下面积(AUC)均高于单一指标检测(P<0.05)。相关性分析结果显示:脐血瘦素、IGFBP-3与GDM孕妇娩出巨大儿呈正相关(P<0.05)。【结论】空腹血糖、脐血瘦素、IGFBP-3联合检测对GDM孕妇娩出巨大儿具有较高的预测价值。

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	代晶芳
	张冬梅
	张倩

关键词 ：糖尿病妊娠, 瘦素, 胰岛素样生长因子结合蛋白质3, 数据相关性

Abstract：【Objective】To explore the correlation between the levels of leptin and insulin-like growth factor binding protein 3 (IGFBP-3) in umbilical cord blood and the delivery of macrosomia in pregnant women with gestational diabetes mellitus (GDM). 【Methods】 A total of 312 pregnant women with GDM who delivered in our hospital from April 2020 to June 2023 were selected. The pregnant women were divided into Group A (macrosomia, neonatal birth weight ≥4 kg) and Group B (non-macrosomia, neonatal birth weight normal or lower than normal weight) according to the birth weight of the newborns. The levels of leptin and IGFBP-3 in umbilical cord blood before delivery were compared between the two groups. We analyzed the influencing factors of macrosomia delivery in pregnant women with GDM to explore the correlation of macrosomia delivery in pregnant women with GDM with umbilical cord blood levels of leptin and IGFBP-3. The predictive value of umbilical cord blood leptin and IGFBP-3 levels for macrosomia delivery in pregnant women with GDM was evaluated. 【Results】The levels of IGFBP-3, umbilical cord blood leptin and fasting blood glucose in group A were all higher than those in group B (P<0.05). The results of binary Logistic regression analysis showed that higher levels of fasting blood glucose, umbilical cord blood leptin, and IGFBP-3 were risk factors for pregnant women with GDM to deliver macrosomia (P<0.05). The results of the receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) of the combined prediction of umbilical cord blood leptin, IGFBP-3, and fasting blood glucose for the delivery of macrosomia in pregnant women with GDM was higher than that of the single index detection (P<0.05). The results of the correlation analysis showed that umbilical cord blood leptin and IGFBP-3 were positively correlated with the delivery of macrosomia in pregnant women with GDM(P<0.05).【Conclusion】The combined detection of fasting blood glucose, umbilical cord blood leptin, and IGFBP-3 has a high predictive value for the delivery of macrosomia in pregnant women with GDM.

Key words： Diabetes Gestational Leptin Insulin-Like Growth Factor Binding Protein 3 Correlation of Data

收稿日期: 2024-05-09

中图分类号:

R714.256

引用本文:

代晶芳, 张冬梅, 张倩. 脐血瘦素、IGFBP-3水平与妊娠期糖尿病孕妇分娩巨大儿的相关性分析[J]. 医学临床研究, 2025, 42(4): 623-625.
DAI Jingfang, ZHANG Dongmei, ZHANG Qian. Correlation Analysis of Macrosomia with Gestational Diabetes Mellitus with Cord Blood Leptin and IGFBP-3 Levels. JOURNAL OF CLINICAL RESEARCH, 2025, 42(4): 623-625.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.04.018 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I4/623

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