Abstract：【Objective】To compare the dosimetric differences in inverse intensity-modulated radiation therapy (IMRT) plans for postoperative concurrent dose escalation in cervical cancer using four different fluence smoothing parameters in the Monaco treatment planning system.【Methods】Forty cervical cancer patients were enrolled in the study. Treatment plans were designed and evaluated under the same optimization conditions using high (High), medium (Medium), low (Low), and no (Off) fluence smoothing parameters. The average dose (Dmean), minimum dose (Dmin), conformity index (CI), homogeneity index (HI), organ at risk (OAR) doses, as well as mechanical parameters such as the number of segments, monitor units (MU), and modulation degree (MD) were compared among the four groups.【Results】No statistically significant differences were observed among the four groups regarding Dmin, Dmean, CI, and HI for the target area (P>0.05).There were not any significant differences in OAR dosimetric parameters in the four groups (P>0.05). However, the High group showed significantly better MU and MD values compared to the other three groups (P<0.05). The estimated plan time showed no significant difference among the groups (P>0.05).【Conclusion】All plans designed with the four different fluence smoothing parameters meet the clinical requirements. The use of the High fluence smoothing parameter with a maximum of 30 control points per field in the design of IMRT plans for postoperative concurrent dose escalation in cervical cancer improves plan efficiency.
曹明鹏, 罗伟明, 吕昌瑾, 李云海, 董海权. Monaco计划系统通量平滑设定对宫颈癌调强放疗计划的影响*[J]. 医学临床研究, 2024, 41(11): 1665-1668.
CAO Mingpeng, LUO Weiming, LYU Changjin, et al. Impact of Fluence Smoothing Setting in Monaco Treatment Planning System on IMRT Plans for Cervical Cancer. JOURNAL OF CLINICAL RESEARCH, 2024, 41(11): 1665-1668.
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2024, Vol. 41 
