Effect of High-purity Urinary Gonadotropin Combined with Letrozole in the Treatment of Infertility Patients with Polycystic Ovary Syndrome
LIU Xing-bu, LEI Sheng-yun, YANG Bao-ling
Department of Obstetrics and Gynecology, Staff Hospital, Bureau of Geology and Mineral Exploration and Development of Shaanxi Province, Xi'an Shaanxi 710054
Abstract：【Objective】 To investigate the effect of high-purity urinary tropulin (Hp-HMG) combined with letrozole in the treatment of infertility patients with polycystic ovary syndrome. 【Methods】 Eighty infertility patients with polycystic ovary syndrome who were treated in our hospital from January 2016 to October 2020 were enrolled. The patients were divided into Hp-HMG plus letrozole group and Hp-HMG group according to the touch ball method. Hp-HMG group received Hp-HMG 75-150 U/d treatment (for 7 consecutive days), Hp-HMG plus letrozole group received letrozole 2.5 mg/d (for 3 consecutive days) plus Hp-HMG 75-150 U /d (for 4 consecutive days). The blood lipid levels, uterus and follicular conditions, ovulation, pregnancy, and adverse reactions were observed. 【Results】 There was no significant difference in serum lipid levels between the two groups before treatment (P>0.05). After treatment, the levels of TC and TG in Hp-HMG plus letrozole group were significantly lower than those in the Hp-HMG group (P<0.05). There was no significant difference in LDL and HDL between the two groups (P>0.05). There were no significant differences in the thickness of endometrium and uterine volume between the two groups before and after treatment (P>0.05). After treatment, the number of mature follicles, the average diameter of mature follicles, the maximum follicle diameter, the number of 10-14 cm follicles, and the number of >14 cm follicles in Hp-HMG plus letrozole group were higher than those in Hp-HMG group (P<0.05). The number of ovulation and the clinical pregnancy rate of Hp-HMG plus letrozole group were higher than those of Hp-HMG group, the difference was statistically significant (P<0.05). There were no ovarian hyperstimulation syndrome, unruptured follicular luteinization syndrome and abnormal blood routine in both groups. One case of redness was found in the Hp-HMG group. 【Conclusion】 Hp-HMG combined with letrozole is safe in the treatment of polycystic ovary syndrome infertility, and can improve ovulation rate and pregnancy rate and improve blood lipid levels.
刘星布, 雷声云, 杨宝玲. 高纯度尿促性腺激素联合来曲唑治疗多囊卵巢综合征不孕患者的疗效观察[J]. 医学临床研究, 2021, 38(5): 680-683.
LIU Xing-bu, LEI Sheng-yun, YANG Bao-ling. Effect of High-purity Urinary Gonadotropin Combined with Letrozole in the Treatment of Infertility Patients with Polycystic Ovary Syndrome. JOURNAL OF CLINICAL RESEARCH, 2021, 38(5): 680-683.
[1] 李方凤.重组人卵泡刺激素与尿促性素对多囊卵巢综合征患者体外受精周期促排卵效果比较[J].中国妇幼保健,2017,32(3):569-571.
[2] GHOMIAN N, KHOSRAVI A, MOUSAVIFAR N. A randomized clinical trial on comparing the cycle characteristics of two different initiation days of letrozole treatment in clomiphene citrate resistant PCOS patients in IUI cycles[J].Int J Fertil Steril,2015,9(1):17-26.
[3] 刘冬.来曲唑联合Hp-HMG对多囊卵巢综合征所致不孕症患者治疗效果研究[J].中国妇幼保健,2019,34(16):3766-3768.
[4] 射幸,苟文丽.妇产科学[M].北京:人民卫生出版社,2013:45-48.
[5] THE R E .Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)[J].Hum Reprod,2004,19(1):41-47.
[6] CHEN Z, ZHANG M, QIAO Y, et al. Effects of letrozole in combination with low-dose intramuscular injection of human menopausal gonadotropin on ovulation and pregnancy of 156 patients with polycystic ovary syndrome[J].Pak J Med Sci,2016,32(6):1434-1438.
[7] 肖莉莎,张攀.卵巢打孔术配合来曲唑和人绒毛膜促性腺激素治疗多囊卵巢综合征效果[J].中国计划生育学杂志,2021,29(2):328-331.
[8] 丁霞,潘长青.来曲唑联合HCG治疗多囊卵巢综合征患者的疗效观察[J].医学临床研究,2019,36(6):1044-1046.
[9] ZHAO Y, RUAN X, MUECK A O. Letrozole combined with low dose highly purified HMG for ovulation induction in clomiphene citrate-resistant infertile Chinese women with polycystic ovary syndrome: a prospective study[J].Gynecol Endocrinol,2017,33(6):462-466.
2021, Vol. 38 
