摘要【目的】探讨溴隐亭两种给药方式治疗高泌乳素血症(HPRL)女性不孕症的临床疗效。【方法】回顾性分析2014年5月至2016年5月在本院诊治的HPRL患者87例,根据给药方式不同分为对照组和观察组。对照组患者采用口服溴隐亭治疗,观察组患者采用阴道给溴隐亭治疗。比较两组治疗后临床症状、血清卵泡刺激素(FSH)、黄体生成激素(LH)、雌二醇(E2)、催乳素(PRL)水平、排卵率、妊娠率、流产率及不良反应率情况。【结果】两组患者治疗后出现月经稀少、闭经、溢乳、多毛及头痛症状的病例数较治疗前减少( P <0.05);两组患者治疗后FSH和E2水平均较治疗前上升,LH、PRL水平较治疗前下降( P <0.05),但两组间上述指标比较差异无统计学意义( P >0.05);两组患者治疗后排卵率、妊娠率及流产率比较差异无统计学意义( P >0.05);观察组患者不良反应发生率低于对照组( P <0.05)。【结论】溴隐亭口服和阴道给药方式治疗HPRL女性不孕症疗效显著,均可改善患者血清性激素水平,控制血清PRL水平,然而阴道给药不良反应发生率低,值得临床推广应用。
Abstract：【Objective】To investigate the clinical efficacy of two administrations of bromocriptine in the treatment of female hyperprolactinemia (HPRL) infertility.【Methods】A total of 87 cases of HPRL patients admitted from May 2014 to May 2016 in our hospital were retrospectively divided into control group and observation group according to the way of administration of bromocriptine. The control group was treated with oral bromocriptine treatment while the observation group were treated by vaginal administration of bromocriptine . Clinical symptoms, serum follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL) levels, ovulation rate, pregnancy rate, abortion rate and adverse reaction rate after treatment in the two groups were compared. 【Results】The number of patients with rare menstruation, amenorrhea, galactorrhea, hirsutism and headache in two groups after treatment was lower than that before treatment ( P < 0.05). After treatment, the levels of FSH and E2 in two groups were higher than those before treatment, while the levels of LH and PRL were lower than those before treatment ( P < 0.05).However, no significant differences were shown between the two groups ( P > 0.05). There were no significant differences in ovulation rate, pregnancy rate and abortion rate between the two groups ( P > 0.05). The adverse reaction rate in the observation group was lower than that in the control group ( P < 0.05). 【Conclusion】Oral and vaginal administration of bromocriptine are effective in treating female hyperprolactinemia infertility. It can improve the serum sex hormone levels and control the level of serum PRL. However, the incidence of adverse reactions to vaginal administration is low, which is worthy of clinical application.
徐晓红, 张蕾, 李宁, 刘清秀. 溴隐亭两种给药方式治疗高泌乳素血症女性不孕症的疗效观察[J]. 医学临床研究, 2018, 35(7): 1320-1322.
XU Xiao-hong, ZHANG Lei, LI Ning, et al. Clinical Efficacy of Two Administrations of Bromocriptine in the Treatment of Female Hyperprolactinemia Infertility. JOURNAL OF CLINICAL RESEARCH, 2018, 35(7): 1320-1322.
2018, Vol. 35 
