Abstract：【Objective】 To investigate the efficacy of continuous renal replacement therapy (CRRT) in patients with severe acute kidney injury (AKI).【Methods】 A total of 92 patients with severe AKI underwent CRRT in our hospital between March 2016 and August 2017 were retrospectively reviewed. Patients were divided into the survival group (n=42 cases) and the death group (n=50 cases) according to the outcomes. The mortality was the main endpoint at 28 days after ICU admission. The The efficacy and related index changes were observed and compared. 【Results】 The hospital stay and ICU stay in the survival group were significantly longer than those in the death group (P<0.05). The unrecovered rate in the survival group was significantly lower than that in the death group (26.19% vs. 76.00%), while the partial recovery rate in the survival group was 57.62% (20/42),which was significantly higher than that in the control group (12.00%, 6/50). The difference was statistically significant (P<0.05). Before the start of CRRT, the MAP and urine volume of the survival group were significantly higher than those of the death group, while the MPV and RDW were significantly lower than those of the death group (P<0.05). After the CRRT, the MPV, PCT and Cys-C of the survival group were significantly lower than those of the death group, and PLT and urine volume were significantly higher than those of death group (P<0.05). Before and after CRRT treatment, the MPV and urine volume in the survival group were significantly higher than those in the death group, while its Cys-C was significantly lower than that in the death group (P<0.05). The multivariate regression analysis showed that preoperative MAP, MPV and postoperative Cys-C were independent factors influencing the prognosis of patients with severe AKI.【Conclusion】 High MAP level is beneficial to the prognosis of severe AKI patients during CRRT.The elevated MPV and Cys-C can be used as independent risk factors for severe AKI mortality.
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2020, Vol. 37 
