Abstract:【Objective】To investigate the bioelectrical impedance analysis evaluating fluid distribution in patients with endstage renal disease (ESRD). 【Methods】Thirty cases of patients with ESRD without hematodialysis (HD) from Jan. 2013 to Jun. 2015 were studied as the nonHD group and another 30 cases undergoing hematodialysis were studied as the HD group.Thirty cases undergoing health examination were used as the control group. Extracellular account body weight percentage (ECV%), intracellular fluid percentage of body weight (ICV), percentage of body weight (TBW%) accounted for the total body water, extracellular/intracellular fluid (ECV/ICV ), and edema index (ECV / TBW) of the cases were determined. 【Results】ECV%: decreased in all three groups; the decrease was most apparent in the nonHD group, less apparent in the HD group, and least apparent in the control group, with significant contrasts between the levels of any two groups (P<0.05). ICV%: there were no significant differences among the three groups (P>0.05). TBW %: those of NonHD group and HD group were not significantly different (P>0.05), although they were higher than that of the control group (P<0.05).. ECV/ICV: decreased most in the nonHD group, less in the HD group, and least in the control group, with significant differences between any two groups (P<0.05). ECV/TBW: decreased most in the nonHD group, less in the HD group, and least in the control group, with significant differences between any two groups (P<0.05). 【Conclusion】Bioelectrical impedance analysis in dialysis patients with endstage renal disease is effective. It will show that ESRD patients have significantly abnormal distribution of body fluids,.mainly, reflecting extracellular fluid increases but without significant effect on the intracellular fluid.Thus, bioelectrical impedance analysis will guide dialysis treatment for ESRD.