叙事护理干预模式对接受免疫治疗后出现不良反应的肺癌患者的影响

doi:10.3969/j.issn.1671-7171.2026.09.010

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Abstract 【Objective】 To investigate the effect of a narrative nursing intervention model on lung cancer patients who experienced adverse reactions after treatment with immune checkpoint inhibitors. 【Methods】 A total of 66 lung cancer patients with immunotherapy-related adverse reactions (≥ grade 2 according to CTCAE) admitted from January 2024 to February 2025 were randomly divided into an observation group and a control group, with 33 patients in each group. Both groups received routine nursing care, while the observation group additionally received narrative nursing intervention. The incidence of new adverse reactions within 4 weeks after intervention, time to adverse reaction relief, anxiety and depression levels [assessed using the Hospital Anxiety Scale (HAMA-14) and Hospital Depression Scale (HAMD-17)], and self-efficacy [assessed using the Strategies Used by People to Promote Health (SUPPH) scale] were compared between the two groups. 【Results】The overall incidence of adverse reactions in the observation group was 21.21% (7/33), which was significantly lower than that in the control group [45.45% (15/33)] (P<0.05). The relief times of rash, pruritus, thyroid dysfunction, gastrointestinal diarrhea, and immune-related pneumonia were shorter in the observation group than in the control group (all P<0.05). After 4 weeks of intervention, the anxiety and depression scores in the observation group were lower than those in the control group (all P<0.05), while all dimensions of the SUPPH scores were higher than those in the control group (all P<0.05). 【Conclusion】The narrative nursing intervention model can significantly reduce the incidence of immunotherapy-related adverse reactions, shorten the duration of adverse reactions, and improve patients' anxiety, depression, and self-efficacy in lung cancer patients.

Key words： Lung Neoplasms Narrative Nursing Care Immunotherapy Adverse Reaction

Received: 28 May 2025

PACS:

R734.2

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	Articles by authors
	JIA Yanan
	ZHANG Yongjing
	JIN Xiaoran

Cite this article:

JIA Yanan,ZHANG Yongjing,JIN Xiaoran. Effect of Narrative Nursing Intervention Model on Lung Cancer Patients Experiencing Adverse Reactions after Immunotherapy[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(9): 1443-1446.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.09.010 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I9/1443

[1] 李凤,梁燕,边原,等.127例非小细胞肺癌免疫治疗不良反应分析[J].中国新药杂志,2024,33(15):1615-1620.
[2] 陈秀梅,陈思涓,甘彬,等.晚期非小细胞肺癌患者免疫治疗不良反应风险因素分析[J].循证医学,2023,23(3):174-180.
[3] 黄爱本,刘佳,庞莉,等.肺癌患者免疫检查点抑制剂相关不良反应的高危因素分析[J].标记免疫分析与临床,2025,32(3):460-465.
[4] 刘淼,于媛.叙事护理在肺癌患者中的应用及研究进展[J].国际护理学杂志,2025,44(1):1-6.
[5] 中华医学会肿瘤学分会,中华医学会杂志社.中华医学会肺癌临床诊疗指南(2023版)[J].中华医学杂志,2023,103(27):2037-2074.
[6] 袁金燕,王焕云,刘晓文,等.叙事护理对肿瘤患者PICC留置期间负性情绪、自我健康行为能力的影响[J].齐鲁护理杂志,2024,30(1):21-24.
[7] 王琳,齐晓莹,纪元元.叙事护理结合链式亲情护理对宫颈癌患者心理状态、癌因性疲乏的影响[J].齐鲁护理杂志,2024,30(23):21-24.
[8] 朱文玲,施如意,徐静静,等.个案管理策略对老年非小细胞肺癌免疫治疗患者的心理状态及生存质量的影响[J].医学临床研究,2025,42(1):128-131.
[9] 王丹,陈群,王艳波,等.临床护士为终末期患者实施本土化叙事护理的体验[J].中国护理管理,2024,24(2):181-186.
[10] 翟艳萍,徐红梅,李润,等. 叙事护理在中青年脑卒中伴急性应激障碍病人中的应用[J].护理研究,2023,37(17):3211-3216.
[11] 陆国涛,马子雪,张芳,等.叙事治疗文件在叙事护理中的应用及展望[J].护理学报,2024,31(8):23-26.
[12] 张文静,梁展鹏,张奡,等.晚期非小细胞肺癌患者免疫治疗所致甲状腺功能减退症的中医证候、证素特点研究[J].广州中医药大学学报,2025,42(2):283-292.
[13] 赵凡斐,郑阳,牛坦倓,等. 抗体偶联药物应用于非小细胞肺癌的不良反应研究进展[J].中国癌症防治杂志,2025,17(1):120-127.
[14] 孙新星,王雅琳,吕望,等.叙事护理对肺癌手术患者症状群管理及创伤后成长的应用研究[J].中国肺癌杂志,2025,28(1):40-46.

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(9): 1562-1565.