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| Predictive Value of Serum miR-122 and IBIL/CYP450 for Neonatal Hyperbilirubinemia Complicated with Bilirubin Encephalopathy |
| ZHANG Mei |
| Department of Pediatrics, Xiayi Maternal and Child Health Hospital, Xiayi Henan 476400 |
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Abstract 【Objective】 To explore the predictive efficacy of miR-122 and IBIL/CYP450 for bilirubin encephalopathy (ABE) in neonates with neonatal hyperbilirubinemia (NHB). 【Methods】 A total of 63 neonates with NHB admitted to our hospital from April 2021 to August 2024 were enrolled as observation group, and divided into complication subgroup (n=22) and simple hyperbilirubinemia subgroup (n=41) according to whether complicated with ABE. Meanwhile, 45 healthy neonates born in our hospital during the same period were selected as control group. Serum levels of miR-122, CYP450 and indirect bilirubin (IBIL) were compared among the three groups. Multivariate logistic regression analysis was used to screen the risk factors of ABE in NHB neonates. Receiver operating characteristic (ROC) curve was plotted to analyze the predictive value of miR-122 and IBIL/CYP450 for ABE in NHB neonates. 【Results】 The levels of miR-122, TSB, IBIL and IBIL/CYP450 in the simple subgroup were higher than those in the control group but lower than those in the complication subgroup (P<0.05). The CYP450 levels in the simple subgroup and complication subgroup were both higher than those in the control group (P<0.05), while there was no significant difference in CYP450 level between the simple subgroup and complication subgroup (P>0.05). Multivariate logistic regression analysis showed that elevated miR-122, TSB, IBIL and IBIL/CYP450 were independent risk factors for ABE in NHB neonates (P<0.05). ROC curve analysis indicated that the combined prediction efficacy of miR-122 and IBIL/CYP450 was superior to that of single index prediction (P<0.05). 【Conclusion】 The combination of miR-122 and IBIL/CYP450 has good application value in predicting ABE in neonates with NHB.
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Received: 06 August 2025
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2026, Vol. 43 
