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| Application Effect of Runfei Tongluo Decoction Combined with Azithromycin in Children with Persistent Cough Due to Mycoplasma Pneumonia of Yinxu Feire Type |
| SHI Yonghui, GAO Shijing |
| Department of Paediatrics,Tongbai County People's Hospital, Nanyang Henan 474750 |
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Abstract 【Objective】To explore the application effect of Runfei Tongluo Decoction combined with azithromycin in children with persistent cough due to mycoplasma pneumonia of Yinxu Feire type. 【Methods】A total of 92 children with persistent cough due to mycoplasma pneumonia admitted to our hospital from October 2021 to June 2024 were selected and divided into the control group and the observation group according to the random number table method, with 46 cases in each group. The control group was treated with azithromycin, and the observation group was treated with Runfei Tongluo Decoction on the basis of the control group, with continuous treatment for 3 weeks. The TCM syndrome scores, clinical efficacy, incidence of adverse reactions, disappearance time of cough and lung rales, and serum levels of leukotriene and high-sensitivity C-reactive protein (hs-CRP) were compared between the two groups. 【Results】After treatment, the scores of primary and secondary syndromes in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05). After treatment, the disappearance time of lung rales, cough and hospital stay in the observation group were shorter than those in the control group, with statistically significant differences (P<0.05). The total clinical effective rate of the observation group was higher than that of the control group, with a statistically significant difference (P<0.05). After treatment, the serum levels of leukotriene and hs-CRP in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group (P=0.503).【Conclusion】 Runfei Tongluo Decoction combined with azithromycin has a good clinical effect in the treatment of children with persistent cough due to mycoplasma pneumonia of Yinxu Feire type, which can reduce inflammatory response with good safety.
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Received: 20 March 2025
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[1] TSAI T A, TSAI C K, KUO K C, et al. Rational stepwise approach for mycoplasma pneumoniae pneumonia in children[J].J Microbiol Immunol Infect,2021,54(4):557-565.
[2] 徐朝晖,沈熔. 麻杏石甘汤加味联合阿奇霉素对肺炎支原体肺炎患儿血清C反应蛋白及临床疗效的影响[J].世界中医药,2019,14(12):3257-3259.
[3] 胡少华,石锦梅,汪江涛. 桑杏汤加减联合阿奇霉素对肺炎支原体感染患儿的疗效[J].西北药学杂志,2022,37(2):140.
[4] 赖东兰,许华,江美容. 叶天士《幼科要略》学术思想及其在儿科的临床应用[J].环球中医药,2018,11(7):1063-1065.
[5] 邵成良. 润肺通络汤联合孟鲁司特钠治疗小儿肺炎支原体感染后咳嗽46例[J].中国中医药科技,2021,28(1):134-135.
[6] 胡亚美,江载芳. 诸福棠实用儿科学[M]. 北京:人民卫生出版社,2002:1204-1205.
[7] 国家中医药管理局. 中医病证诊断疗效标准[M]. 南京:南京大学出版社,1994:76-77.
[8] DAI F F, LIU F Q, CHEN X, et al. The treatment of macrolide-resistant mycoplasma pneumoniae pneumonia in children[J].J Clin Pharm Ther,2021,46(3):705-710.
[9] BIAGI C, CAVALLO A, ROCCA A, et al. Pulmonary and extrapulmonary manifestations in hospitalized children with mycoplasma pneumoniae infection[J].Microorganisms,2021,9(12):2553.
[10] CHEN Y C, HSU W Y, CHANG T H, et al. Macrolide-resistant mycoplasma pneumoniae infections in pediatric community-acquired pneumonia[J].Emerg Infect Dis,2020,26(7):1382-1391.
[11] 许遵贤,赵艳. 《幼科心法要诀》中“凉膈散”治疗儿科病刍议[J].中医药导报,2019,25(17):10-11.
[12] 刘小敏,庄承,梅玉霞,等. 豁痰通络汤治疗儿童难治性肺炎支原体肺炎的临床效果及对免疫功能的影响[J].广西医学,2020,42(20):2639-2642.
[13] 袁方. 肺炎汤与穴位敷贴联合西药治疗儿童痰热壅肺型肺炎支原体肺炎临床研究[J].新中医,2022,54(2):126-130.
[14] 程燕,张赛. 清肺通络法治疗儿童肺炎支原体肺炎干咳[J].河南中医,2017,37(2):257-259.
[15] 徐菁. 沙参麦冬汤合芍药甘草汤治疗肺炎支原体感染后小儿咳嗽60例[J].中国中医药科技,2012,19(2):101. |
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2025, Vol. 42 
