美沙拉嗪肠溶片联合维生素D对溃疡性结肠炎患者肠道屏障功能和炎症因子的影响

doi:10.3969/j.issn.1671-7171.2025.07.022

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Abstract 【Objective】To explore the effects of mesalazine enteric-coated tablets combined with vitamin D on intestinal barrier function and inflammatory factors in patients with ulcerative colitis (UC). 【Methods】 A total of 96 UC patients admitted to our hospital from March 2020 to March 2023 were selected and divided into the control group and the observation group according to the random number table method, with 48 cases in each group. The control group was treated with mesalazine enteric-coated tablets, and the observation group was treated with mesalazine enteric-coated tablets combined with vitamin D on the basis of the control group. The clinical efficacy, intestinal mucosal barrier function indexes [serum diamine oxidase (DAO), D-lactic acid (D-LA), intestinal fatty acid binding protein (I-FABP)], intestinal flora (lactobacillus, bifidobacterium, enterobacterium), inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6)], endoscopic lesion indexes (Baron score, Mayo score) and incidence of adverse reactions were compared between the two groups. 【Results】The total effective rate of the observation group was 97.92% (47/48), which was higher than 79.17% (38/48) of the control group, with a statistically significant difference (χ²=8.317, P<0.05). After treatment, the serum levels of DAO, D-LA and I-FABP in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05); the number of enterobacteria in both groups was lower than that before treatment, and the observation group was lower than the control group; the numbers of lactobacillus and bifidobacterium in both groups were higher than those before treatment, and the observation group was higher than the control group, with statistically significant differences (P<0.05); the serum levels of TNF-α, IL-1β and IL-6 in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05); the Baron score and Mayo score in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】Mesalazine enteric-coated tablets combined with vitamin D can effectively enhance the intestinal mucosal barrier function of UC patients, reduce the levels of inflammatory factors, regulate intestinal flora, and has high safety.

Key words： Colitis, Ulcerative Mesalamine Vitamin D Chemokines

Received: 19 February 2024

PACS:

R574.62

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	Articles by authors
	CUI Huibin
	LIU Xiaokai
	FENG Wei

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CUI Huibin,LIU Xiaokai,FENG Wei. Effects of Mesalazine Enteric-Coated Tablets Combined with Vitamin D on Intestinal Barrier Function and Inflammatory Factors in Patients with Ulcerative Colitis[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(7): 1181-1184.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.07.022 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I7/1181

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