新疆维吾尔族与山东汉族胃癌患者的临床病理特征<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2025.07.003

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Abstract 【Objective】To compare the clinicopathological characteristics of patients with gastric carcinoma in Xinjiang Uyghur and Shandong Han ethnic groups. 【Methods】A total of 144 specimens of primary gastric cancer surgically resected in Shandong Provincial Third Hospital and the Third Clinical Medical College of Xinjiang Medical University (Affiliated Cancer Hospital) from January 2018 to December 2020 were collected, including 94 cases of Han ethnicity in Shandong (Han group) and 50 cases of Uyghur ethnicity in Xinjiang (Uyghur ethnicity group). The clinicopathological characteristics and HER2 expression of gastric cancer in the two groups were compared. 【Results】 The average age of onset of gastric cancer in the Uyghur group was lower than that in the Han group, and the proportion of patients aged 40-65 in the Uyghur group was higher than that in the Han group. The proportion of male patients in both groups of gastric cancer patients was higher than that of female patients. The proportion of gastric cancer located at the gastroesophageal junction in the Uyghur group was higher than that in the Han group. The proportion of poorly differentiated gastric cancer in the Uyghur group was higher than that in the Han group, while the proportion of moderately differentiated gastric cancer was lower than that in the Han group. The proportion of diffuse and intestinal-type gastric cancer in the Han group was higher than that in the Uyghur group, while the proportion of mixed gastric cancer was lower than that in the Uyghur group. The expression rate of HER2 protein 3⁺ in gastric cancer tissues of the Uyghur group was lower than that of the Han group, while the expression rate of HER2 protein 2⁺ was higher than the Han group. The number of HER2-negative intestinal and mixed gastric cancer patients in the Uyghur group was lower than in the Han group, while the number of HER2-positive mixed gastric cancer patients with han was higher than in the Uygur group. The difference in HER2 protein expression was correlated with ethnicity, tumor differentiation degree, and Lauren classification (P<0.05). 【Conclusion】Gastric cancer patients of Uyghur ethnicity in Xinjiang and Han ethnicity in Shandong have different clinicopathological characteristics. The differences in HER2 protein expression in gastric cancer with different racial genetic backgrounds may affect the prognosis of patients.

Key words： Stomach Neoplasms Uygur Nationality Han Nationality Pathological Conditions, Signs and Symptoms

Received: 20 April 2023

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R735.2

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.07.003 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I7/1112

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