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| Correlation of Toll-Like Receptor 4, Nuclear Factor-κB and Interleukin-17 Levels with Wheezing in Children with Mycoplasma Pneumonia |
| LI Linnan, WANG Yongfang, LIAN Huijuan |
| Clinical Laboratory, Zhengzhou First People's Hospital, Zhengzhou Henan 450000 |
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Abstract 【Objective】To investigate the relationship of the levels of Toll-like receptor 4 (TLR4), nuclear factor-κB (NF-κB) and interleukin-17 (IL-17) with the occurrence of wheezing in children with mycoplasma pneumonia (MP). 【Methods】 A total of 82 children with MP were enrolled, Based on the presence of clinical symptoms of wheezing and auscultatory findings of wheezing sounds, the children with wheezing were assigned to the observation group, and those without wheezing were assigned to the control group. The serum levels of TLR4, NF-κB, and IL-17 were compared between the two groups. Logistic regression analysis was used to assess the relationship of levels of TLR4, NF-κB and IL-17 with the occurrence of wheezing in the children. The receiver operating characteristic (ROC) curve was employed to evaluate the predictive value of these markers for the occurrence of wheezing in the children with mycoplasma pneumonia. 【Results】 The levels of TLR4, IL-17, and NF-κB in the observation group were significantly higher than those in the control group (all P<0.05). Logistic regression analysis revealed that the levels of TLR4, NF-κB, and IL-17 were positively correlated with the risk of wheezing in the children (all P<0.05). The ROC curve indicated that the combined detection of serum TLR4, NF-κB, and IL-17 had significantly higher sensitivity, specificity, and area under the curve for predicting wheezing in children with MP compared with the detection of a single marker (all P<0.05). 【Conclusion】 Elevated levels of TLR4, NF-κB, and IL-17 are significantly associated with an increased risk of wheezing in children with MP. The combined detection of these three markers exhibits high predictive sensitivity and specificity.
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Received: 21 April 2025
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2025, Vol. 42 
