T淋巴细胞亚群、HBsAg、HBeAg评估乙肝患者不同病理状态的临床价值

doi:10.3969/j.issn.1671-7171.2025.02.027

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Abstract 【Objective】To investigate the clinical value of T lymphocyte subsets, hepatitis B surface antigen (HBsAg) and hepatitis Be antigen (HBeAg) in evaluating different pathological states of patients with hepatitis B.【Methods】A total of 85 cases of hepatitis B patients admitted to our hospital from May 2020 to May 2023 were selected. Pathological examination results showed that 48 cases had inflammation grade < 2, of which 37 cases had inflammation grade ≥2, of which 36 cases had fibrosis stage < 2, and 49 cases had fibrosis stage ≥2. The levels of HBsAg, HBeAg and T lymphocyte subsets in patients with different fibrosis stages and inflammatory grades were compared, and the clinical value of HBsAg,HBeAg and T lymphocyte subsets were analyzed by receiver operating characteristic (ROC) curve to evaluate the different pathological status of hepatitis B patients.【Results】The levels of HBsAg and HBeAg in patients with fibrosis stage ≥2 were significantly lower than those with fibrosis stage < 2, the difference was statistically significant (P<0.05). There was no significant difference in CD4⁺ and CD8⁺ levels among hepatitis B patients with different fibrosis stages (P>0.05). ROC curve analysis showed that HBsAg and HBeAg levels had better clinical efficacy in predicting fibrosis stage ≥2, and the area under the curve were 0.772 and 0.821, respectively (P<0.05). HBsAg, HBeAg and CD8⁺ levels in patients with inflammation grade ≥2 were significantly lower than those with inflammation grade < 2, and CD4⁺ levels were significantly higher than those with inflammation grade < 2, with statistical significance (P<0.05). ROC curve analysis showed that HBsAg, HBeAg, CD4⁺, CD8⁺ levels had better clinical efficacy in predicting inflammation grade ≥2, and the area under the curve was 0.785, 0.808, 0.644, 0.683, with statistical significance (P<0.05).【Conclusion】HBsAg and HBeAg levels and immune function are abnormal in patients with hepatitis B in different pathological states, and the levels of HBsAg, HBeAg and T lymphocyte subsets can be jointly detected in clinic to better evaluate the disease progression of patients.

Key words： Hepatitis B T-Lymphocyte Subsets Hepatitis B Surface Antigens Hepatitis B e Antigens

Received: 21 November 2023

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R512.62

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.02.027 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I2/268

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