纳布啡辅助抑制腹腔镜胆囊切除术麻醉诱导时舒芬太尼诱发呛咳反应的效果

doi:10.3969/j.issn.1671-7171.2025.02.011

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Abstract 【Objective】To investigate the effect of nalbuphine in suppressing the cough reflex induced by sufentanil during anesthesia induction for laparoscopic cholecystectomy (LC).【Methods】A total of 82 patients undergoing LC were randomly divided into the observation group and the control group, with 41 patients in each group. Both groups were administered sufentanil for anesthesia induction. Ten minutes before induction, the control group received 0.01 mg/kg of penehyclidine hydrochloride intravenously, while the observation group received 0.01 mg/kg of penehyclidine hydrochloride plus 0.1 mg/kg of nalbuphine intravenously. The incidence of cough reflex, hemodynamic and stress marker changes, pain levels, and adverse reactions were compared between the two groups.【Results】The incidence of cough reflex was lower in the observation group than in the control group (P<0.05). There was no significant difference in the duration of cough reflex between the two groups (P>0.05). At 2 minutes after sufentanil injection (T₂), the mean arterial pressure (MAP) and heart rate (HR) were lower in both groups compared to 10 minutes before injection (T₀) and 1 minute after injection (T₁) (P<0.05), and they were lower at T₁ than at T₀ (P<0.05). MAP and HR at T₁ and T₂ were higher in the observation group compared to the control group (P<0.05). The numerical rating scale (NRS) pain scores at 4 hours (T₄) and 24 hours (T₅) postoperatively were lower than at T₃ in both groups (P<0.05), and the scores at T₅ were lower than at T₄ (P<0.05); however, there was no significant difference in NRS scores between the two groups at any time point (P>0.05). At 24 hours postoperatively, adrenaline and norepinephrine levels were elevated compared to preoperative levels in both groups (P<0.05), but there was no significant difference between the groups (P>0.05). The overall incidence of adverse reactions was not significantly different between the two groups (P>0.05).【Conclusion】Nalbuphine effectively suppresses sufentanil-induced cough reflex during anesthesia induction for LC, with minimal impact on hemodynamics. It alleviates postoperative pain and is safe and reliable.

Key words： Cholecystectomy, Laparoscopic Nalbuphine Sufentanil Anesthesia

Received: 12 October 2024

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R657.4

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	SONG Pei

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SONG Pei. The Effect of Nalbuphine in Assisting the Suppression of Sufentanil-Induced Cough Reflex during Anesthesia Induction for Laparoscopic Cholecystectomy[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(2): 214-217.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.02.011 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I2/214

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