The Clinical Efficacy of Lamotrigine Combined with Topiramate in the Treatment of Children with Epilepsy and its Impact on Cognitive Function and Neurotrophic Factor Levels in Patients
CHEN Jing, YANG Juping, JIN Hongguang, et al
The Second Hospital of Jiaozuo,Jiaozuo Henan 454000
Abstract 【Objective】To explore the clinical efficacy of lamotrigine combined with topiramate in the treatment of children with epilepsy and its impact on cognitive function and neurotrophic factor levels in patients.【Methods】A retrospective analysis was conducted on the clinical data of 56 children with epilepsy admitted to our hospital from February 2021 to December 2022. According to different treatment plans, the children were divided into a control group (treated with lamotrigine) and an observation group (treated with lamotrigine and topiramate), with 28 cases in each group. Two groups were compared in terms of clinical efficacy, electroencephalogram efficacy, pre-treatment and post-treatment seizure status, neurokine levels [neuropeptide Y (NPY), insulin-like growth factor-1 (IGF-1), brain-derived neurotrophic factor (BDNF), intercellular adhesion molecule-1 (ICAM-1)], cognitive function [Wechsler Intelligence Scale (WISC-Ⅳ) score], anxiety and depression [Hamilton Anxiety Scale (HAMA) and Depression Scale (HAMD) score].【Results】The clinical effective rate and total effective rate of EEG in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the frequency and duration of seizures in both groups were lower than before treatment, and the observation group was lower than the control group, with a statistically significant difference (P<0.05). After treatment, the WISC-Ⅳ score of the observation group was higher than that of the control group, and the HAMA and HAMD scores were lower than those of the control group (P<0.05). After treatment, the serum levels of NPY, IGF-1, BDNF, and ICAM-1 in both groups were lower than before treatment, and the observation group was lower than the control group, with statistical significance (P<0.05). 【Conclusion】The combination of lamotrigine and topiramate has a good clinical efficacy in the treatment of pediatric epilepsy, which can reduce the number of seizures, promote neurological function recovery, improve cognitive function, and alleviate anxiety and depression.
CHEN Jing,YANG Juping,JIN Hongguang, et al. The Clinical Efficacy of Lamotrigine Combined with Topiramate in the Treatment of Children with Epilepsy and its Impact on Cognitive Function and Neurotrophic Factor Levels in Patients[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(4): 565-568.
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