Abstract 【Objective】To explore the relationship between platelet (PLT) related parameters, PLT reactive protein 1 (TSP-1) levels, and disease activity in patients with systemic lupus erythematosus (SLE). 【Methods】A total of 83 SLE patients admitted to our hospital were selected as the observation group, and 62 healthy individuals who underwent physical examinations during the same period were selected as the control group. Two groups of general information, biochemical indicators, PLT related parameters, and TSP-1 levels were compared; Logistic multiple regression analysis was used to identify the factors influencing disease activity in SLE patients, and receiver operating characteristic (ROC) curve analysis was used to evaluate the value of PLT parameters and TSP-1 in evaluating disease activity in SLE patients. 【Results】 The PLT count, PLT volume, and percentage of large PLT in the observation group were all lower than those in the control group (P<0.05). The average PLT volume (MPV), PLT volume distribution width (PDW), and TSP-1 level in the observation group were higher than those in the control group (P<0.05). Logistic multiple regression analysis showed that IgG, MPV, C3, C4, PLT, and TSP-1 levels were related factors affecting disease activity in SLE patients (P<0.05). ROC curve analysis showed that the sensitivity of MPV, PLT, TSP-1, and their combined evaluation for disease activity in SLE patients were 72.41%, 75.86%, 68.97%, and 79.31%, respectively. The specificity was 70.37%, 79.63%, 77.78%, and 83.33%, respectively. The area under the curve (AUC) was 0.723, 0.751, 0.739, and 0.892, respectively.【Conclusion】 MPV, PLT, and TSP-1 in PLT parameters are related to disease activity in SLE patients, and their combined evaluation of disease activity in SLE patients has good efficacy as evaluation indicators.
ZHU Guizhi,WANG Feng,QU Yan, et al. The Relationship between Platelet Parameters, Platelet Reactive Protein 1 Levels, and Disease Activity in Patients with Systemic Lupus Erythematosus[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(2): 258-261.
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