头孢类抗生素致敏红细胞检测与溶血性贫血的关系

doi:10.3969/j.issn.1671-7171.2024.02.019

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Abstract 【Objective】To explore the relationship between cephalosporin antibioticsensitized red blood cell detection and hemolytic anemia. 【Methods】Blood samples of 996 patients who were hospitalized in our hospital for blood type testing and blood transfusion preparation were collected in the study. Antiglobulin cassette method was used to detect drug-sensitized red blood cells for direct antiglobulin test (DAT) positive status. Statistics of clinical DAT test results with patients' distribution in clinical departments was analyzed. Anti-globulin cassette method was used for antibody typing of DAT positive blood samples, DAT positive intensity distribution, classification, cephalosporin antibiotic sensitized red blood cell detection, and DAT positive antibiotic types. The relationship between cephalosporin antibiotic sensitized red blood cell detection and hemolytic anemia was analyzed by clinically investigating whether patients had hemolytic anemia. The blood group automatic analyzer was used to detect the positive status of the drug-sensitized red blood cell direct antiglobulin test (DAT) and the clinical DAT test results were counted.【Results】The positive detection rate of DAT was 7.83%, and the positive rate of DAT in internal medical department was higher than that in surgical department (P<0.05). The reaction intensities (1+,2+,3+ and 4+) of the blood samples of 78 DAT positive patients in the antiglobulin card accounted for 28.21%, 24.36%, 25.64%, and 21.79%, respectively. While there was no statistical difference in the distribution of the reaction intensity (P>0.05). The proportions of anti-IgG, anti-C3d, and anti-IgG+C3d in DAT positive classification were 39.74%, 33.33%, and 26.92%, respectively. However, there was no significant difference in the composition of DAT positive classification (P>0.05). In the blood samples of 78 DAT positive patients in this study, a total of 9 cases of erythrocytes sensitized to 4 antibiotics were detected; And the proportion of erythrocytes sensitized to cefaclor was higher than that of cefoperazone-sulbactam sodium, cefepime, ceftazidime (P<0.05). There was no significant difference among the other antibiotics (P>0.05). In the blood samples of DAT positive patients in this study, the incidence of clinical hemolytic anemia in antibiotics users was higher than that of no antibiotics users (P<0.05); And the incidence of hemolytic anemia in antibiotics sensitized red blood cells was higher than that of antibiotic unsensitized patients (P<0.05). There was not statistically significant in the incidence of hemolytic anemia between non-sensitized patients who used antibiotics and those who did not use antibiotics (P>0.05).【Conclusion】There is a certain correlation between cephalosporin antibiotic sensitized red blood cell detection and hemolytic anemia.

Key words： Cephalosporins/AE Anemia, Hemolytic Correlation of Data

Received: 08 September 2022

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R556.6

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	CHEN Qi
	CHEN Xuan
	YOU Lan
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Cite this article:

CHEN Qi,CHEN Xuan,YOU Lan, et al. Analysis of the Relationship between Cephalosporin Antibiotic Sensitized Red Blood Cell Detection and Hemolytic Anemia[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(2): 226-229.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.02.019 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I2/226

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