血清GFAP、MMP-9检测对高血压脑出血患者神经功能损伤程度的预测价值

doi:10.3969/j.issn.1671-7171.2024.02.015

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Abstract 【Objective】To explore the relationship between glial fibrillary acidic protein (GFAP), matrix metalloproteinase-9 (MMP-9) and the degree of neurological damage in patients with hypertensive intracerebral hemorrhage (HICH).【Methods】A total of 102 HICH patients and 85 hypertensive patients without cerebral hemorrhage were recorded as HICH group and hypertensive group, respectively. Another 80 healthy individuals who underwent physical examination were selected as the health group. Three groups of GFAP and MMP-9 levels were compared; The National Institutes of Health Stroke Scale (NIHSS) was used to evaluate the degree of neurological damage in HICH patients, and based on this, they were divided into mild, moderate, and severe groups. We compared the levels of GFAP and MMP-9 in HICH patients with different degrees of neurological deficits. Pearson correlation analysis was used to investigate the correlation between GFAP, MMP-9 levels and the degree of neurological damage in HICH patients. After a 6-month follow-up, the prognosis of HICH patients was evaluated based on the Glasgow Outcome Scale (GOS), and the levels of GFAP and MMP-9 were compared between the group with good prognosis and the group with poor prognosis. A receiver operating characteristic curve (ROC) was created to analyze the predictive value of GFAP, MMP-9, and their combination on the prognosis of HICH patients using area under the curve (AUC).【Results】The levels of GFAP and MMP-9 in patients with hypertension and HICH were higher than those in the healthy group (P<0.05); The levels of GFAP and MMP-9 in the HICH group were higher than those in the hypertension group (P<0.05). The levels of GFAP and MMP-9 in patients in the moderate and severe groups were higher than those in the mild group (P<0.05); The levels of GFAP and MMP-9 in the severe group were higher than those in the moderate group (P<0.05). The levels of GFAP and MMP-9 in HICH patients are positively correlated with the degree of neurological damage (P<0.05). The levels of GFAP and MMP-9 in the poor prognosis group were higher than those in the good prognosis group (P<0.05). The ROC results showed that the AUC of GFAP, MMP-9, and their combination for predicting the prognosis of HICH patients were 0.978, 0.884, and 0.925, respectively. GFAP had the highest predictive value for the prognosis of HICH patients. 【Conclusion】Serum levels of GFAP and MMP-9 are related to the degree of neurological damage and prognosis in HICH patients, and have a high predictive power for patient prognosis.

Key words： Intracranial Hemorrhage, Hypertensive Glial Fibrillary Acidic Protein/BL Matrix Metalloproteinase 9/BL

Received: 02 August 2023

PACS:

R743.2

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	HUANG Lina
	LI Xianglei
	ZHANG Haijun

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HUANG Lina,LI Xianglei,ZHANG Haijun. The Predictive Value of Serum GFAP and MMP-9 Detection for Neurological Damage in Patients with Hypertensive Intracerebral Hemorrhage[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(2): 210-213.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.02.015 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I2/210

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