血清HbF、AFP水平及BPS、Apgar评分诊断胎儿母体输血综合征的价值

doi:10.3969/j.issn.1671-7171.2024.02.014

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1281 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To explore the value of serum fetal hemoglobin (HbF), alpha fetoprotein (AFP), combined with fetal biophysical score (BPS) and Apgar score in the diagnosis of fetal maternal transfusion syndrome (FMH) in pregnant and postpartum women. 【Methods】A total of 100 pregnant and postpartum women suspected of FMH were selected as the study subjects in our outpatient department. After delivery, the serum HbF and AFP levels of pregnant and postpartum women were measured, and they were divided into FMH group (13 cases) and non FMH group (87 cases) based on the test results; We compared the HbF, AFP levels, BPS, and Apgar scores between two groups of pregnant women. The value of HbF, AFP, BPS, and Apgar scores in predicting FMH was analyzed using Receiver Operating Characteristic (ROC) curves; The multiple factor analysis adopted unconditional logistic stepwise regression analysis. 【Results】The levels of HbF and AFP in the FMH group were significantly higher than those in the non FMH group, and the BPS and Apgar scores were significantly lower than those in the non FMH group (all P<0.05); According to ROC analysis, HbF, AFP, BPS, and Apgar scores can be used to predict the occurrence of FMH. The area under the curve was 0.897, 0.810, 0.829, and 0.941, respectively, and the area under the joint diagnostic curve was 0.980; Multiple logistic regression analysis confirmed that HbF≤3.712%, AFP≤588.359 ng/mL, BPS≥5.865 scores, and Apgar score ≥5.96 scores were risk factors for the occurrence of FMH.【Conclusion】The combination of serum HbF, AFP, BPS, and Apgar score can be used for early diagnosis of FMH, and the combined detection has better evaluation efficacy.

Key words： Fetomaternal Transfusion Fetal Hemoglobin alpha-Fetoproteins Apgar Score

Received: 28 February 2023

PACS:

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.02.014 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I2/207

[1] 倪萍,蔡敏,黄利辉,等. 6例胎母输血综合征早期识别及救治[J].实用妇产科杂志,2022,38(9):715-718.
[2] 范可欣,朱鹏汇,王云,等. 长沙地区孕妇胎母输血综合征发生率及危险因素分析[J].中国输血杂志,2022,35(10):1031-1034.
[3] 罗力冰,唐海燕,李之朋. 双绒毛膜双羊膜囊双胎妊娠一胎胎母输血综合征一例[J].中华围产医学杂志,2020,23(4):257-259.
[4] BASCHAT AA, GALAN HL, LEE W, et al. The role of the fetal biophysical profile in the management of fetal growth restriction[J].Am J Obstet Gynecol,2022,226(4):475-486.
[5] 张志伟. 胎母输血综合征[J].中国实用妇科与产科杂志,2011,27(3):238-240.
[6] 刘莹. 产前母血胎儿有核红细胞、甲胎蛋白水平与胎母输血综合征的相关性分析[J].中国妇幼保健,2017,32(20):4963-4965.
[7] 马莉. 孕期保健联合孕妇课堂健康教育在改善高龄孕妇妊娠结局和围生儿Apgar评分中的应用[J].中国妇幼保健,2019,34(11):2435-2437.
[8] 张瑾,池晶晶,张蕊,等. 孕前肥胖及超重女性的孕期管理模式探讨及肥胖相关胎盘因子分析[J].首都医科大学学报,2022,43(5):774-781.
[9] 郑刘芳,刘清秀,李娟. miR-125在不同孕期生殖道B族溶血性链球菌感染中的表达及与母婴不良结局的关系[J].中国性科学,2020,29(7):73-76.
[10] 陈冠初,姚亚鹏,唐建明,等. 胎儿血红蛋白水平与早产儿常见并发症相关性的研究进展[J].中华新生儿科杂志,2022,37(4):377-380.
[11] 杨岚,石锦平,吴晓,等. 早孕期血清PAPP-A检测联合中孕期血清AFP、freeβ-HCG、uE 3检测对DS、ES的筛查效果[J].山东医药,2017,57(35):18-21.
[12] 康琼英,温洁新,任世豪,等. 胎母输血综合征的特征识别及治疗[J].中国性科学,2020,29(1):101-104.
[13] 吴海莲,黄凤精,陈力. 阿司匹林联合低分子肝素对胎儿生长受限患者胎儿发育、AFI及BPS分值的影响分析[J].中国优生与遗传杂志,2020,28(4):467-469.
[14] CHEN H Y, CHAUHAN S P. Apgar score at 10 minutes and adverse outcomes among low-risk pregnancies[J].J Matern Fetal Neonatal Med,2022,35(25):7109-7118.
[15] 王雅丽,张丽娜,吴青青. 多种胎儿宫内监测方法预测子痫前期新生儿不良结局的比较研究[J].临床超声医学杂志,2021,23(4):261-265.