血浆溶血磷脂酸受体1水平对高血压脑出血患者预后的预测价值

doi:10.3969/j.issn.1671-7171.2024.01.020

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Abstract 【Objective】 To explore the predictive value of plasma lysophosphatidic acid receptor 1 (LPAR1) levels on the prognosis of hypertensive intracerebral hemorrhage patients. 【Methods】 A total of 130 patients with hypertensive intracerebral hemorrhage admitted to our hospital from March 2016 to March 2020 were selected as the observation group, and 50 healthy individuals who underwent physical examinations at our hospital during the same period were selected as the control group. The plasma LPAR1 levels of two groups were detected using enzyme-linked immunosorbent assay (ELISA), and all patients were divided into a good prognosis group (n=67) and a poor prognosis group (n=63) based on the Glasgow Outcome Scale (GOS) scores after 30 days of onset. The factors affecting the poor prognosis of patients in the observation group were analyzed using multiple logistic regression, and the receiver operating characteristic (ROC) curve was plotted to evaluate the predictive value of plasma LPAR1 levels and poor prognosis in patients with hypertensive intracerebral hemorrhage. 【Results】 The plasma LPAR1 levels in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). The difference in bleeding volume, NIHSS score, and treatment plan between the group with good prognosis and the group with poor prognosis was statistically significant (P<0.05). The plasma LPAR1 levels in patients with poor prognosis were higher than those in those with good prognosis, and the difference was statistically significant (P<0.05). Multivariate logistic regression analysis showed that LPAR1>4.22 μg/L and NIHSS score>(23.62±2.55) scores were independent risk factors for poor prognosis in patients with hypertensive intracerebral hemorrhage (P<0.05). ROC curve analysis showed that the AUC of plasma LPAR1 level for diagnosing poor prognosis in patients with hypertensive intracerebral hemorrhage was 0.857 (95%CI: 0.753-0.869), with a cutoff value of 3.68 μmol/L, with sensitivity and specificity of 81.3% and 85.6%, respectively.【Conclusion】 Plasma LPAR1 levels have certain predictive value for the prognosis of patients with hypertensive intracerebral hemorrhage, and can provide some reference for early clinical evaluation of patient prognosis.

Key words： Intracranial Hemorrhage, Hypertensive Receptors, Lysophosphatidic Acid/BL Prognosis

Received: 26 August 2022

PACS:

R743.2

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	LIU Tao
	ZHANG Hui
	XU Fanye

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LIU Tao,ZHANG Hui,XU Fanye. The Predictive Value of Plasma Lysophosphatidic Acid Receptor 1 Levels on the Prognosis of Hypertensive Intracerebral Hemorrhage Patients[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(1): 74-77.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.01.020 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I1/74

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