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| Predictive Value of RDW Combined with hs-cTnT on Left Ventricular Diastolic Dysfunction in MHD Patients |
| SHI Xiao-yan, SHEN Ying-chun |
| Laboratory Department,People's Hospital of Yuyang District, Yuyang Shaanxi 719000 |
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Abstract 【Objective】To analyze the predictive value of red blood cell distribution width (RDW) combined with high-sensitivity troponin T (hs-cTnT) in maintenance hemodialysis (MHD) patients with left ventricular diastolic dysfunction. 【Methods】A total of 80 MHD patients in our hospital from April 2019 to February 2021 were selected. The serum hs-cTnT level and RDW level of the patients before dialysis were collected. In addition,Doppler ultrasound was used to detect the early diastolic wave (E') and early diastolic peak flow rate (E) of the mitral valve. According to the test results,patients were divided into the diastolic dysfunction group and normal diastolic function group according to the test results. Logistic multivariate regression analysis was used to investigate the related factors affecting left ventricular diastolic dysfunction in patients; And receiver operating characteristic curve (ROC) was used to determine the effects of RDW and hs-cTnT levels on predictive value for patients to have complication with left ventricular diastolic disfunction. 【Results】Among the 80 MDH patients,49 cases (61.25%) had left ventricular diastolic dysfunction,and 31 patients (38.75%) had normal left ventricular diastolic function. The diastolic dysfunction group has a higher proportion of diabetes history,RDW,water load,and hs-cTnT level compared to the normal diastolic group. The ultrafiltration volume/BMI level of the diastolic dysfunction group was lower than that of the normal diastolic group (P<0.05). Logistic multivariate regression analysis showed that a history of diabetes,RDW,high water load,hs-cTnT expression level and low ultrafiltration volume/BMI expression level were the risk factors for left ventricular diastolic dysfunction in MDH patients (P<0.05). ROC analysis showed that the area under the curve (AUC) of RDW and hs-cTnT single and combined predictions for patients with left ventricular diastolic dysfunction were 0.804,0.807,and 0.888,respectively. The predictive power of RDW and hs-cTnT alone on patients with left ventricular diastolic dysfunction was lower than that of the combination of the two measurements (P<0.05). 【Conclusion】MHD patients with high expression levels of RDW and hs-cTnT are more likely to have left ventricular diastolic dysfunction. Thus,RDW and hs-cTnT have certain clinical predictive value for MHD patients with left ventricular diastolic dysfunction.
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Received: 13 April 2022
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2022, Vol. 39 
