Abstract 【Objective】To investigate the correlation between thromboelastography (TEG) and coagulation indicators in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). 【Methods】All 106 patients with AECOPD were recruited from our hospital between January 2018 and January 2020. The coagulation indicators and TEG were detected. The correlation between TEG and coagulation indicators was analyzed by Pearson correlation. At the same time,patients were divided into the low-risk group (n=61) and the high-risk group (n=45),according to the number of AECOPD attacks and changes in lung function in the past year. Receiver operating characteristic (ROC) curve was used to explore the value of TEG in estimating risk of COPD. 【Results】Pearson correlation analysis showed that K (clot formation time) and R (coagulation factor activation time) had positively correlated with APTT (activated partial thrombin time),and the correlation coefficient correlation were 0.361 and 0.428,respectively. Meanwhile,MA (maximum clot strength)was positively correlated with FIB (fibrinogen),while MA was negatively correlated to D-D (D-dimer); and the correlation coefficient were 0.537 and -0.381,respectively. The K and R in the low-risk group were significantly shorter than high-risk group; the coagulation index (CI) was significantly lower than that of the high-risk group (P<0.05). The area under curve (AUC) of R time,K time and CI in the high-risk COPD were 0.87(0.81-0.94),0.80(0.71-0.89),and 0.66(0.56-0.77),respectively,and their optimal threshold was 3.62 min,4.75 min and 2.04,respectively. 【Conclusion】TEG was correlated with coagulation indicators in patients with AECOPD,and it can be used to identify high-risk COPD patients.
PAN Jie-ping,ZHANG Hai-hua. Correlation between Thromboelastography and Coagulation Indicators in Patients with AECOPD[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(12): 1834-1836.
2022, Vol. 39 
