|
|
|
| Effect of Atorvastatin on Pathological Changes of Aortic Valve in the Model of Hyperlipidemia Rabbits |
| SHI Chuang, LI Ji-yong, WANG Po, et al |
| Daxing Teaching Hospital of Capital Medical University,Beijing 102600 |
|
|
|
|
Abstract 【Objective】To investigate the effect of atorvastatin on the pathological changes of aortic valve induced by hyperlipidemia in rabbits. 【Methods】 A total of 39 healthy male New Zealand white rabbits were selected and divided into atorvastatin intervention diet high fat group (AI group), normal diet control group (N group) and simple high fat diet group (HC group) according to random number table. At 4, 8 and 12 weeks after the start of the experiment, venous blood was taken to measure the plasma lipid level, and aortic valve echocardiography was performed at 8 and 12 weeks after the start of the experiment. The morphological changes of valves in each group were analyzed, and the aortic valve markers were taken for histological examination. 【Results】 The levels of serum total cholesterol (TC), C-reactive protein (CRP), triacylglycerol (TG) and low-density lipoprotein cholesterol (LDL-C) in the group HC were significantly higher than those in the group AI and the group N (P<0.05); The levels of serum TC, TG, CRP and LDL-C in the group AI at 8 and 12 weeks were higher than those in the group N and lower than those in thegroup HC (P<0.05). At 12 weeks, the echocardiographic aortic valve in the group HC showed thickening and echo enhancement, and with the prolongation of high-fat diet, there was a tendency of valve calcification and decreased activity; Echocardiographic valve changes in the group AI were less severe than those in the group HC; There was no significant change in the group N before and after echocardiography. HE staining of aortic valve in the group HC showed endothelial injury, deposition of lipid calcium salt, growth of fibrous tissue and inflammatory reaction caused by macrophage infiltration; The pathological changes in the group AI were less severe than those in the group HC. 【Conclusion】 Atorvastatin can significantly delay the process of aortic valve disease induced by hyperlipidemia.
|
|
Received: 22 December 2021
|
|
|
|
|
|
[1] KLEINAUSKIENE. R,JONKAITIENE. R.Degenerative aortic stenosis,dyslipidemia and possibilities of medical treatment[J].Medicina(Kaunas),2018,54(2):24.
[2] RAUSCH M K,TIBAYAN F A,INGELS N B,et al.Mechanisms of mitral annular in chronic ischemic cardiomyopathy[J].Ann Biomed Eng,2013,41(10):2171-2180.
[3] 任瞳,李继勇,张健群,等.阿托伐他汀对兔主动脉瓣钙化性病变炎症反应影响的研究[J].心肺血管病杂志,2018,37(4):5.
[4] JUNG J J,JADBABAIE F,SADEGHI M M.Molecular imaging of calcific aortic valve disease[J].J Nucl Cardiol,2018,25(4):1148-1155.
[5] ISSA H,L HÉNAUT, ABDALLAH J B,et al.Activation of the calcium-sensing receptor in human valvular interstitial cells promotes calcification[J].J Mol Cell Cardiol,2019,129:2-12.
[6] 田军.ATF6在钙化性主动脉瓣膜中的表达及意义[D].上海:海军军医大学,2019.
[7] 潘丹,苏微微,李立,等.匹伐他汀对脑梗死患者的多效性及安全性研究[J].中国医院用药评价与分析,2020,20(10):4.
[8] 陈俊,沈珈谊,韦铁民.钙化性主动脉瓣膜疾病的临床研究进展[J].心脑血管病防治,2020,20(6):608-612.
[9] 任莉.超声诊断老年钙化性心脏瓣膜病的临床价值分析[J].影像研究与医学应用,2021,5(5):185-186.
[10] 戴敬,吕树铮,宋现涛.围手术期阿托伐他汀钙序贯治疗对急性ST段抬高性心肌梗死患者组织灌注和临床预后的探讨[J].心肺血管病杂志,2015,34(1):7-11.
[11] 沈迎念,张莉伟,辜刚建,等.阿托伐他汀钙抑制心脏瓣膜成肌纤维细胞向成骨细胞样表型转化[J].中国医院药学杂志,2015,6(35):1057-1060.
[12] 刘思佳.心脏彩色多普勒超声在老年钙化性心脏瓣膜病诊断中的应用[J].临床医学,2021,10(41):29-30. |
|
|
|
2022, Vol. 39 
