Abstract 【Objective】To observe the expression and clinical application value of MACC1 and c-Met in different tissues of gastric cancer patients. 【Methods】The clinical data of 133 patients with gastric cancer who underwent radical surgical treatment were retrospectively analyzed. The expression of MACC1 and hepatocyte growth factor receptor (c-Met) were detected in cancerous and adjacent tissues after surgery. The positive protein detection rates of MACC1 and c-Met,and the relative mRNA expression levels of MACC1 and c-Met in different tissues were compared. The positive detection rates of MACC1 and c-Met in gastric cancer patients with different clinicopathological features were compared as well. Finally,the difference in postoperative survival rate of patients with positive and negative MACC1 and c-Met were follow-up.【Results】The positive detection rates of MACC1 and c-Met in cancerous tissues were significantly higher than those in adjacent tissues (P<0.05).The relative expression levels of MACC1 mRNA and c-Met mRNA in cancer tissues were significantly higher than those in adjacent tissues (P<0.05).There were no significant differences in the positive detection rates of MACC1 and c-Met in cancer tissues of patients with different gender,age,tumor diameter,tumor location and tissue type (P>0.05).The positive rates of MACC1 and c-Met were significantly increased in patients with TNM stage Ⅲ or Ⅳ,infiltration depth T3 or T4,Lauren's intestinal type,low differentiation or undifferentiation,lymph node metastasis (P<0.05). The 3-year mortality was 33.08%(44/133). Kaplan-meier survival analysis showed that the higher the positive rate of MACC1and c-Met in cancer tissue,the lower the survival rate of patients (P<0.05).【Conclusion】High expression of MACC1 and c-Met in cancer tissues of gastric cancer patients is closely related to the progression,invasion,metastasis prognosis of the disease.
WANG Rong,JIAO Xin-yan. MACC1 and c-Met Expression and Clinical Value in Different Tissues of Patients with Gastric Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(8): 1217-1220.
2022, Vol. 39 
