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| MACC1 and c-Met Expression and Clinical Value in Different Tissues of Patients with Gastric Cancer |
| WANG Rong, JIAO Xin-yan |
| Department of Oncology,Baoji High-tech Hospital,Baoji Shaanxi 721000 |
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Abstract 【Objective】To observe the expression and clinical application value of MACC1 and c-Met in different tissues of gastric cancer patients. 【Methods】The clinical data of 133 patients with gastric cancer who underwent radical surgical treatment were retrospectively analyzed. The expression of MACC1 and hepatocyte growth factor receptor (c-Met) were detected in cancerous and adjacent tissues after surgery. The positive protein detection rates of MACC1 and c-Met,and the relative mRNA expression levels of MACC1 and c-Met in different tissues were compared. The positive detection rates of MACC1 and c-Met in gastric cancer patients with different clinicopathological features were compared as well. Finally,the difference in postoperative survival rate of patients with positive and negative MACC1 and c-Met were follow-up.【Results】The positive detection rates of MACC1 and c-Met in cancerous tissues were significantly higher than those in adjacent tissues (P<0.05).The relative expression levels of MACC1 mRNA and c-Met mRNA in cancer tissues were significantly higher than those in adjacent tissues (P<0.05).There were no significant differences in the positive detection rates of MACC1 and c-Met in cancer tissues of patients with different gender,age,tumor diameter,tumor location and tissue type (P>0.05).The positive rates of MACC1 and c-Met were significantly increased in patients with TNM stage Ⅲ or Ⅳ,infiltration depth T3 or T4,Lauren's intestinal type,low differentiation or undifferentiation,lymph node metastasis (P<0.05). The 3-year mortality was 33.08%(44/133). Kaplan-meier survival analysis showed that the higher the positive rate of MACC1and c-Met in cancer tissue,the lower the survival rate of patients (P<0.05).【Conclusion】High expression of MACC1 and c-Met in cancer tissues of gastric cancer patients is closely related to the progression,invasion,metastasis prognosis of the disease.
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Received: 04 December 2020
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[1] PYO J H,LEE H,MIN B H,et al. Long-term outcome of endoscopic resection vs. surgery for early gastric cancer:a non-inferiority-matched cohort study[J].Am J Gastroenterol,2016,111(2):240-249.
[2] 秦建领,秦名扬. 结肠癌转移相关因子1和肝细胞生长因子受体在非小细胞肺癌中的表达及意义[J].中国临床医生杂志,2017,45(4):56-58.
[3] 马涛,李丹,杨翠宏. 卵巢癌组织中miR-338-3p,MACC1的表达变化及意义[J].山东医药,2020,60(16):18-21.
[4] GAO F,DENG G,LIU W,et al. Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway[J].Oncol Rep,2017,37(2):1203-1211.
[5] 廖专,孙涛,吴浩,等. 中国早期胃癌筛查及内镜诊治共识意见(2014年4月·长沙)[J].中华消化杂志,2014,34(7):433-448.
[6] 马大烈,白辰光. 免疫组织化学阳性标记结果的观察和判断[J].临床与实验病理学杂志,2003,19(5):557-559.
[7] LIVAK KJ,SCHMITTGEN TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-△△CT method[J].Methods,2001,25(4):402-408.
[8] STEIN U,WALTHER W,ARLT F,et al. MACC1,a newly identified key regulator of HGF-MET signaling,predicts colon cancer metastasis[J].Nat Med,2009,15(1):59-67.
[9] 李保勤,艾波. C-met、IGF-1R蛋白表达与胃癌相关性分析[J].医学临床研究,2019,36(5):1012-1014.
[10] 骆婕,郭妹,吴瑾柔,等. 结肠癌转移相关因子-1、肝细胞生长因子和C-met信号通路在子宫内膜异位症中的表达[J].实用医学杂志,2019,35(6):88-91.
[11] SONGUN I,VELDE C,ARENDS J W,et al. Classification of gastric carcinoma using the Goseki system provides prognostic information additional to TNM staging[J].Cancer,2015,85(10):2114-2118.
[12] 丁平安,杨沛刚,田园,等. 70岁及以上胃癌患者的临床病理特征及预后分析[J].中华老年医学杂志,2021,40(1):96-101.
[13] 顾荣民,陈环球,明学志,等. MACC-1mRNA和c-MetmRNA在胃癌组织中的表达及其临床意义[J].实用老年医学,2011,25(6):477-479. |
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(9): 1409-1411. |
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2022, Vol. 39 
