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| Effect of p53 Expression on Prognosis in Triple Negative Breast Cancer |
| YANG Xi-jia, LIU Qi |
| Department of General Surgery, Xi'an High-Tech Hospital, Xi'an 710061 |
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Abstract 【Objective】To explore the expression of p53 in triple-negative breast cancer and its relationship with prognosis. 【Methods】A total of 79 patients with operable triple-negative breast cancer treated in our hospital were selected. Fresh cancer tissues and adjacent tissues were collected during operation, and p53 expression was detected by immunohistochemistry. The patients were followed up to observe the recurrence, metastasis and overall survival (OS). The relationship of p53 expression with recurrence, metastasis and OS was analyzed. 【Results】The positive expression rate of p53 (40.51%) in triple-negative breast cancer was higher than that in adjacent tissues (11.39%), and the difference was statistically significant(P<0.05).The proportion of N3 and grade Ⅲ in p53 high expression group was higher than that in p53 low expression group (both P<0.05). The follow-up time was 36-60 (49.6 ± 4.9) months. A total of 70 patients were followed up and 9 were lost to follow-up. A total of 17 patients relapsed. Of which, the recurrence rate in the p53 high expression group was significantly higher than that in the p53 low expression group, and the difference was statistically significant(P<0.05). A total of 11 patients had metastasis. The metastasis rate in the p53 high expression group (32.14%) was significantly higher than that in the p53 low expression group, and the difference was statistically significant(P<0.05). During the follow-up period, 17 patients died. Kaplan-Meier method and Log-rank test results showed that patients with triple-negative breast cancer plus high expression of p53 had shorter OS than those patients with triple-negative breast cancer plus low expression of p53 (P<0.05). Multivariate COX results showed that tumor size (T), lymph node stage (N), p53 expression, and histological grade were independent prognostic factors affecting the death of triple-negative breast cancer patients (P<0.05). 【Conclusion】The p53 expression is up-regulated in triple negative breast cancer, and patients with high p53 expression have a poor prognosis and high risk of recurrence, metastasis, and death.
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Received: 16 October 2020
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2021, Vol. 38 
