BRCA1、MIC-1、mTOR在老年结直肠癌组织中的表达及其临床意义<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2021.01.010

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Abstract 【Objective】To investigate the expression and clinical significance of BRCA1, macrophage inhibitory cytokine-1 (MIC-1) and mammalian rapamycin target protein (mTOR) in elderly colorectal cancer.【Methods】 From March 2015 to March 2018, 75 cases of elderly colorectal cancer tissues and corresponding adjacent normal tissues were selected. The expression of BRCA1, MIC-1 and mTOR in colorectal cancer tissues and adjacent normal tissues were detected by immunohistochemistry (SP); The correlation between the expression of BRCA1, MIC-1, mTOR and clinicopathological data was analyzed, and the influence of BRCA1, MIC-1 and mTOR on tumor free survival was analyzed after operation. 【Results】 The positive expression rate of BRCA1 in colorectal cancer tissues was significantly lower than that in adjacent normal tissues (P<0.05). The positive expression rates of MIC-1 and mTOR in colorectal cancer tissues were significantly higher than those in adjacent normal tissues (P<0.05). There was no significant correlation between BRCA1 expression and clinicopathological data such as age, gender, lymph node metastasis, tumor differentiation and TNM stage (P>0.05). The positive expression of MIC-1 was significantly correlated with TNM stage (P<0.05), and the positive expression of mTOR was significantly correlated with tumor differentiation and TNM stage (P<0.05). The tumor free survival of patients with BRCA1 positive expression was significantly better than that of patients with negative expression of BRCA1 (P<0.05), and that of patients with negative expression of MIC-1 and mTOR was significantly better than those with positive expression (P<0.05).【Conclusion】BRCA1 is low expression in colorectal cancer, MIC-1 and mTOR were highly expressed in colorectal cancer, and the three were related to the prognosis of elderly patients with rectal cancer.

Key words： Colorectal Neoplasms/PA Genes BRCA1 Tacrolimus Binding Proteins Immunohistochemistry

Received: 26 December 2018

PACS:

R735.37

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	Articles by authors
	SHI Cheng-ying
	QI Ya-wen
	SHI Cheng-ling

Cite this article:

SHI Cheng-ying,QI Ya-wen,SHI Cheng-ling. Expression and Clinical Significance of BRCA1, MIC-1 and mTOR in Elderly Colorectal Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(1): 32-34.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.01.010 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I1/32

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