老年阻塞性睡眠呼吸暂停低通气综合征患者记忆损伤及认知障碍的情况分析

doi:10.3969/j.issn.1671-7171.2021.03.014

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1195 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To observe the memory and cognitive impairment in elderly patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). 【Methods】We selected 96 elderly OSAHS patients (OSAHS group) from January 2017 to December 2019 in our hospital, whose sleep apnea hypopnea index (AHI) times was more than 5 times/hour. In the same period, 40 elderly health checkups who participated this study were selected as the control group (SHIm: 0 times/h≤AHI≤5 times/h). Furthermore, the OSAHS Patients were divided into two groups according to the sleep apnea hypopnea index (AHI): the mild-moderate OSAHS group (56 patients, 5 times/h <AHI≤30 times/h) and the severe OSAHS group (40 patients, AHI> 30 times/h). The three groups of subjects received polysomnography (PSG), overall cognition, short-term memory, attention and executive ability tests'. Thus, the cognitive impairment and memory impairment were compared in the three groups. 【Results】The proportion of ODI (oxygen reduction index), AHI, RRMAI (respiratory related micro awakening index), NREM (non-rapid eye movement) sleep stage Ⅰ to Ⅱ ratio, severe cognitive dysfunction, TMT A use time, and TMT B use time in the severe OSAHS group were higher than those in the non-OSAHS group and mild-moderate OSAHS group ( P <0.05). LSaO₂ (nocturnal pulse oxygen at night), NREM Ⅲ stage ratio, MMSE (simple mental state examination) scale score, MocA (Montreal cognitive assessment) scale score, DST (digital span test) forward, DST backward, CFT (complex graph test) redraw scores were lower than those in the mild to moderate OSAHS group and the non-OSAHS group ( P <0.05). The proportion of cognitive dysfunction, TMT A use time, and TMT B use time in the mild-to-moderate OSAHS group were higher than those in the non-OSAHS group ( P <0.05); and the MMSE, MoCA score, DST forward, DST reverse, and CFT redraw scores were lower than those in the non-OSAHS group ( P <0.05). Correlation analysis results showed that AHI was positively correlated with TMT A use time and TMT B use time ( P <0.05), and AHI was negatively correlated with DST forward, DST reverse, CFT redraw, MMSE, and MoCA ( P <0.05). 【Conclusion】OSAHS has memory impairment, cognitive impairment and decreased attention and execution ability. As the disease worsens, the degree of memory impairment and cognitive impairment plus the attention and execution ability decreases, which should draw important attention clinically.

Key words： Sleep Apnea Obstructive/PP Syndrome Memory Disorders Cognition Disorders Aged

Received: 15 January 2021

PACS:

R56

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	GU Liang
	XU Dong-hui
	DU Chun-ling

Cite this article:

GU Liang,XU Dong-hui,DU Chun-ling. Study on Memory Impairment and Cognitive Impairment in Elderly Patients with Obstructive Sleep Apnea-Hypopnea Syndrome[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(3): 368-371.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.03.014 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I3/368

[1] 赵立梅,谢娟.阻塞性睡眠呼吸暂停低通气综合征的研究进展[J].中国慢性病预防与控制,2019,27(2):144-147.
[2] 王明香,郭运凯.阻塞性睡眠呼吸暂停低通气综合征患儿外周血8-异前列腺素F2α、细胞黏附分子-1的表达及其意义[J].医学临床研究,2019,36(12):2447-2449.
[3] 高茜,姜琳琳,王丽妍, 等.单纯鼾症与阻塞性睡眠呼吸暂停低通气综合征患者睡眠期间的有效通气量、血氧浓度及睡眠和生活质量的比较[J].医学临床研究,2019,36(4):643-644.
[4] 邢昊昱. 阻塞性睡眠呼吸暂停低通气综合征与认知功能障碍的研究进展[J].实用医学杂志,2019,35(1):10-13.
[5] 中华医学会,中华医学会杂志社,中华医学会全科医学分会, 等.成人阻塞性睡眠呼吸暂停基层诊疗指南(实践版·2018)[J].中华全科医师杂志,2019,18(1):30-35.
[6] 王洪敏,王洲羿,倪小红, 等.多导睡眠图在不同亚型帕金森患者睡眠质量分析中的应用价值[J].广西医科大学学报,2019,36(6):993-997.
[7] 杨立新,唐旋,周宁, 等.北京版蒙特利尔认知评估量表在成人OSAHS认知功能评估中的应用及可靠性验证[J].临床耳鼻咽喉头颈外科杂志,2018,32(1):58-64.
[8] 李琪,李宁真,李婷婷, 等.中青年阻塞性睡眠呼吸暂停低通气综合征患者注意力及短期记忆损伤的研究[J].中华结核和呼吸杂志,2019,42(6):419-425.
[9] Semelka M, Wilson J, Floyd R.Diagnosis and Treatment of Obstructive Sleep Apnea in Adults[J]. Am Fam Physician, 2016,94(5):355-360.
[10] 杨生岳,黄宁侠,冯恩志.阻塞性睡眠呼吸暂停低通气综合征患者认知功能障碍的相关研究进展[J].中华肺部疾病杂志(电子版),2016,9(3):337-340.
[11] 赵阿敏,黄晓波.阻塞性睡眠呼吸暂停低通气综合征患者认知功能障碍的研究进展[J].世界睡眠医学杂志,2019,6(11):1633-1636.
[12] Gagnon K.Detection of mild cognitive impairment in middle-aged and older adults with obstructive sleep apnoea[J]. Eur Respir J, 2018,52(5):1801137.
[13] 吴美娟,魏晓丽.阻塞型睡眠呼吸暂停低通气综合征患者轻度认知功能障碍的调查分析[J].护理实践与研究,2019,16(19):47-48.
[14] Stranks EK, Crowe SF.The cognitive effects of obstructive sleep apnea: an updated meta-analysis[J]. Arch Clin Neuropsychol, 2016,31(2):186-193.