老年脑梗死患者继发血管性痴呆的危险因素分析<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2021.03.005

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Abstract 【Objective】To explore the risk factors of vascular dementia (VD) in elderly patients with cerebral infarction. 【Methods】 A total of 193 elderly patients with cerebral infarction were selected for the study. According to the occurrence of VD, the patients were divided into the VD group (74 cases) and the non VD group (119 cases). General data of the two groups were compared. Risk factors for VD were evaluated by Logistic regression analysis, and the diagnostic efficacy of VD was analyzed using receiver operating characteristic curve (ROC). Pearson was used to explore the correlation among various factors and analyze the expression of risk factors in different degrees of dementia. 【Results】The multivariate analysis showed that age (OR=4.926, P <0.05), >6 years of Education ( OR =1.953, P <0.05), infarct area ( OR =5.147, P <0.05), severe vascular stenosis ( OR =3.031, P <0.05), hypertension ( OR =2.853, P <0.05), vascular endothelial growth factor (VEGF) level ( OR =5.452, P <0.05), and brain Neurotrophic factor (BDNF) ( OR =4.524, P <0.05) were independent influencing factors of VD after cerebral infarction. Particularly, age >60 years old, severe stenosis of blood vessels, hypertension, infarct area >7.18 cm², VEGF<4.47ng/mL and BDNF<236.83 pg/mL patients need to be alert to the occurrence of VD. Correlation analysis showed that age was positively correlated with infarct size and negatively correlated with VEGF and BDNF. VEGF was positively correlated with BDNF. The levels of VEGF and BDNF increased with the severity of dementia, and the number of severe vascular stenosis and the number of hypertension increased with the severity of dementia as well. 【Conclusion】 Elderly patients with older age of primary cerebral infarction, large infarct area, high blood pressure (hypertension), high VEGF and BDNF level increase the probability of VD, while the elderly with more years of education may reduce the risk of VD.

Key words： Brain Infarction/CO Dementia Vascular/CO Aged Risk Factors

Received: 22 June 2019

PACS:

R743.33

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	XUE Yan-hua
	LI Jing
	YU Qi-jin
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Cite this article:

XUE Yan-hua,LI Jing,YU Qi-jin, et al. Risk Factors for Vascular Dementia in Elderly Patients with Cerebral Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(3): 339-342.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.03.005 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I3/339

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