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| Relationship of MCL-1 and NIBP Expression in Colon Cancer Tissues with Tumor Progression |
| FAN Yu-chen, MA Yue-zhen, LI Kai-nan |
| Shandong Provincial Third Hospital,Jinan Shandong,250031,China |
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Abstract 【Objective】To investigate relationship of the expression of myeloid leukemia gene-1 (MCL-1) and NIK-IKK binding protein (NIBP) with tumor progression in colon cancer. 【Methods】Immunohistochemical staining was used to detect the expression of MCL-1 protein and NIBP protein in 82 cases of postoperative colon cancer tissues and corresponding adjacent tissues. The pathological parameters such as different TNM stage, tumor differentiation degree and lesion size were analyzed to reveal their relationship with positive expression rate of MCL-1 protein and NIBP protein. 【Results】The positive rates of MCL-1 protein and NIBP protein in colon cancer tissues were 68.29% and 60.98%, respectively, which were significantly higher than those in adjacent tissues (26.83% and 20.73%, respectively). The differences were statistically significant (P<0.05). The differential expression of MCL-1 protein and NIBP protein in colon cancer tissues with different tumor invasion depths, TNM stages, pathological differentiation, and lymph node metastasis were statistically significant (P<0.05). 【Conclusion】The expression of MCL-1 protein and NIBP protein in colon cancer tissues is significantly higher than that in adjacent tissues, which may be related to the progression of colon cancer.
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Received: 13 August 2020
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2020, Vol. 37 
