丁苯酞联合神经节苷脂静脉滴注对急性脑梗死患者神经功能及生活质量的影响

doi:10.3969/j.issn.1671-7171.2020.11.023

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Abstract 【Objective】To investigate the effect of Butylphthalide Combined with Ganglioside on preventing reperfusion injury and quality of life in patients with cerebral infarction. 【Methods】The clinical data of 126 patients with acute cerebral infarction admitted to the Department of Neurosurgery of our hospital from March 2014 to October 2018 were retrospectively analyzed. According to the different treatment drugs, they were divided into control group (n=63, receiving butylphthalide intravenous drip) and observation group (n=63, receiving butylphthalide combined with ganglioside intravenous drip). After 15 days of treatment, the NIHSS score of neurological function and Barthel score of activities of daily living of the two groups were compared to evaluate the therapeutic effect of the two groups. The serum levels of neuron specific enolase (NSE), S100 β protein, superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor-α(TNF-α), C-reactive protein (CRP) were detected and compared between the two groups before and after treatment. 【Results】After 15 days of treatment, the NIHSS scores of the two groups were decreased compared with those before treatment, and the observation group was significantly lower than the control group, the differences were statistically significant (P<0.05); the Barthel scores of the two groups were improved, and the observation group was significantly higher than the control group, the differences were statistically significant (P<0.05). The levels of NSE, S100β, MDA, TNF-αand CRP in the two groups were lower than those before treatment, and the indexes in the observation group were significantly lower than those in the control group (P<0.05); the serum SOD levels in the two groups were higher than those before treatment, and the observation group was higher than the control group, the differences were statistically significant (P<0.05). After treatment, the total effective rate of the observation group was 93.7% (59/63), significantly higher than 76.2% (48/63) of the control group, the difference was statistically significant (P<0.05).【Conclusion】Butylphthalide combined with ganglioside intravenous drip can improve the neurological function of patients with acute cerebral infarction, promote the recovery of neurological function, improve the quality of life, and improve the therapeutic effect of cerebral infarction. The mechanism may be related to the reduction of oxidative stress and inflammatory injury.

Key words： Brain Infarction/DT Acute Disease Propiophenones/PD Gangliosides/PD Quality of Life

Received: 21 November 2018

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R743.33

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	ZHU Xiao-dun

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ZHU Xiao-dun. Effect of Butylphthalide Combined with Ganglioside Intravenous Drip on Neurological Function and Quality of Life in Patients with Acute Cerebral Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(11): 1674-1677.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.11.023 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I11/1674

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