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| Relationship of Peripheral Blood CTCs with Development and Prognosis of Colon Cancer |
| HU Zuo-yu, CUI Zheng-lyu, FENG Wei |
| Zhidan County People's Hospital, shaanxi, yanan 717500 |
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Abstract 【Objective】To investigate the relationship of circulating tumor cells (CTCs) in peripheral blood with the development and prognosis of colon cancer. 【Methods】A total of 87 patients who underwent surgical treatment of colon cancer in our hospital were selected in the observation (colon cancer) group, and 85 patients with colon polyps who were treated with intestinal polyps were selected as the control group. The levels of CTCs in the peripheral blood of the two groups were measured. The positive rate of peripheral blood CTCs in the group and different CTCs positive rates in colon cancer patients with different pathological features were analyzed. All patients were followed up for 3 years to evaluated the difference in 3-year survival rate and survival time between CTCs positive and negative colon cancer patients. 【Results】The detection rate of CTCs positive cells in peripheral blood of colon cancer group was 44.83%, which was significantly higher than that of control group (3.53%). The difference was statistically significant (P<0.05). The detection rate of CTCs positive cells in peripheral blood of colon cancer patients with different TNM stages, lymph node metastasis, and vascular invasion were compared between groups; and the difference was statistically significant (P<0.05). The positive cells of CTCs in peripheral blood of colon cancer patients with different degrees of differentiation and different tumor sites were detected. The difference between the two groups was not statistically significant (P>0.05). The survival rate analysis showed that the 3-year cumulative survival rate of patients with CTCs positive group was 19.10%, which was lower than that of the negative group (45.20%) (P<0.05). The median survival time was 28.0 months in the CTCs positive group and 35.0 months in the negative group (P<0.05). 【Conclusion】Detection of CTCs positive cells in peripheral blood of patients with colon cancer has certain guiding significance for disease assessment and prognosis.
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Received: 17 August 2020
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2020, Vol. 37 
