Abstract【Objective】To investigate the correlation between the expression of bone morphogenetic protein-2 (BMP-2) in serum and synovial fluid and KL grade and clinical evaluation of osteoarthritis disease activity index (WOMAC) score in patients with osteoarthritis (OA).【Methods】Fifty patients with OA were selected as the observation group and 50 healthy people were randomly selected as the control group. The expression of BMP-2 protein in serum and synovial fluid of OA patients and serum of healthy people was detected so as to analyze the correlation between BMP-2 protein expression in serum and synovial fluid of patients with OA and KL grade and WOMAC score.【Results】The expression level of BMP-2 protein in serum of OA patients was significantly higher than that of healthy people (P<0.05). The expression of BMP-2 protein in serum and synovial fluid of OA patients increased with the increase of KL classification among different KL classification subgroups (P<0.05). At the same time, BMP-2 expression in synovial fluid was significantly higher than that in serum in patients with OA and the same KL grade (P<0.05). The expression of BMP-2 protein in serum and synovial fluid of patients with OA was positively correlated with OA KL grade and WOMAC score.【Conclusion】The expression level of BMP-2 in serum and synovial fluid of OA patients is significantly higher than that of healthy people, and with the increase of KL classification, the expression level of BMP-2 in serum and synovial fluid increase gradually.The expression level of BMP-2 in serum and synovial fluid of patients with OA was positively correlated with KL grade and WOMAC, which may be valuable in evaluating the severity of OA.
LI Jun,ZHANG Lao-zhui. Association of BMP-2 Expression in Serum and Synovial Fluid with KL Grade and WOMAC Score in Patients with Osteoarthritis[J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(7): 1302-1304.
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2019, Vol. 36 
