血清α-羟丁酸脱氢酶和乳酸脱氢酶水平对脑出血患者预后的预测价值

doi:10.3969/j.issn.1671-7171.2026.09.028

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Abstract 【Objective】 To investigate the predictive value of serum α-hydroxybutyrate dehydrogenase (α-HBDH) and lactate dehydrogenase (LDH) levels for the prognosis of patients with intracerebral hemorrhage (ICH). 【Methods】 The clinical data of 101 patients with ICH admitted to Jinshui District General Hospital of Zhengzhou from March 2019 to March 2022 were retrospectively studied. According to their survival status within 28 days after admission, the patients were divided into a favorable-prognosis group (survivors) and an unfavorable-prognosis group (deaths). General clinical data and serum α-HBDH and LDH levels were compared between the two groups. Multivariate Logistic regression analysis was performed to identify factors associated with prognosis in patients with ICH. Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of serum α-HBDH and LDH levels for prognosis in patients with ICH. 【Results】 Among the 101 patients with ICH, 77 survived within 28 days (the favorable-prognosis group) and 24 died (the unfavorable-prognosis group), yielding a mortality rate of 23.76% (24/101). There were no statistically significant differences between the two groups in terms of sex, age, body mass index, level of consciousness at admission, history of hypertension, history of hyperlipidemia, history of diabetes mellitus, fever at admission, time from onset to admission, treatment regimen, respiratory rate, or platelet count (all P>0.05). The unfavorable-prognosis group had a greater hemorrhage volume, a higher proportion of patients with multiple organ failure, and higher serum α-HBDH and LDH levels than the favorable-prognosis group (all P<0.05). Multivariate Logistic regression analysis showed that hemorrhage volume, multiple organ failure, and serum α-HBDH and LDH levels were independent risk factors for poor prognosis in patients with ICH (all P<0.05). ROC curve analysis showed that the area under the curve (AUC), sensitivity, and specificity of the combined α-HBDH and LDH model for predicting prognosis in patients with ICH were higher than those of either marker alone (all P<0.05). 【Conclusion】 Serum α-HBDH and LDH levels are closely associated with the prognosis of patients with ICH, and their combined detection provides greater predictive value for prognosis than either marker alone.

Key words： Cerebral Hemorrhage α-Hydroxybutyrate Dehydrogenase Lactate Dehydrogenase Prognosis

Received: 17 March 2025

PACS:

R743.34

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	ZHANG Weiwei
	CHANG Hui
	SHI Zhipeng

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ZHANG Weiwei,CHANG Hui,SHI Zhipeng. Serum α-Hydroxybutyrate Dehydrogenase and Lactate Dehydrogenase Levels as Predictors of Prognosis in Patients with Intracerebral Hemorrhage[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(9): 1511-1514.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.09.028 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I9/1511

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